SML1548
THPN
≥98% (HPLC)
别名:
1-(2,4,6-Trihydroxyphenyl)-1-nonanone, 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, CID 3063200
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关于此项目
经验公式（希尔记法）:
C15H22O4
化学文摘社编号:
分子量:
266.33
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 25 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1
InChI
1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3
InChI key
NVFRHTFJDGAFQS-UHFFFAOYSA-N
一般描述
THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.
生化/生理作用
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma.
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.
其他说明
air sensitive
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L et al
Nature Chemical Biology, 11(5), 339-346 (2015)
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