SML1548
THPN
≥98% (HPLC)
别名:
1-(2,4,6-Trihydroxyphenyl)-1-nonanone, 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, CID 3063200
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关于此项目
经验公式（希尔记法）:
C15H22O4
化学文摘社编号:
分子量:
266.33
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1
InChI
1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3
InChI key
NVFRHTFJDGAFQS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
Quality Level
General description
THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.
Biochem/physiol Actions
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma.
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.
Other Notes
air sensitive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L et al
Nature Chemical Biology, 11(5), 339-346 (2015)
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