SML1548
THPN
≥98% (HPLC)
别名:
1-(2,4,6-Trihydroxyphenyl)-1-nonanone, 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, CID 3063200
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 25 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1
InChI
1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3
InChI key
NVFRHTFJDGAFQS-UHFFFAOYSA-N
一般描述
THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.
生化/生理作用
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma.
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.
其他说明
air sensitive
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L et al
Nature Chemical Biology, 11(5), 339-346 (2015)
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