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Merck
CN

SML1565

Sigma-Aldrich

A-196

≥98% (HPLC)

别名:

环戊基-（6,7-二氯-4-吡啶-4-基-酞嗪-1-基）-胺

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关于此项目

经验公式（希尔记法）:
C18H16Cl2N4
CAS Number:
1982372-88-2
分子量:
359.25
MDL编号:
MFCD29924807
UNSPSC代码:
12171501
PubChem化学物质编号:
329825968
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to light brown

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1

InChI

1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)

InChI key

ABGOSOMRWSYAOB-UHFFFAOYSA-N

相关类别

生化/生理作用

A-196是SUV420H1和SUV420H2的一种有效且选择性的化学抑制剂，可抑制多种细胞系中H4K20me的二甲基和三甲基化。有关表征的完整详细信息，请访问结构基因组学联盟（SGC）网站上的 A-196 探针摘要 。

SGC2043是活性探针A-196的阴性对照。若需向SGC索要阴性对照样品，请 点击这里。

想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
A-196是SUV420H1和SUV420H2的一种有效和选择性化学抑制剂。

特点和优势

A-196是一种表观遗传化学探针，通过与Structural Genomics Consortium（SGC）合作获得。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。
该化合物是基因调控研究推荐产品。点击此处 ，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000173390
0000173391
0000173391
0000173390
0000107329

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The DNA damage response is mediated by both DNA repair proteins and epigenetic markers. Here, we observe that N6-methyladenosine (m6A), a mark of the epitranscriptome, was common in RNAs accumulated at UV-damaged chromatin; however, inhibitors of RNA polymerases I and
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Nature communications, 12(1), 2490-2490 (2021-05-05)
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk. Here, we report that DNA
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