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Merck
CN

SML1565

A-196

≥98% (HPLC)

别名:

环戊基-（6,7-二氯-4-吡啶-4-基-酞嗪-1-基）-胺

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关于此项目

经验公式（希尔记法）:
C18H16Cl2N4
化学文摘社编号:
1982372-88-2
分子量:
359.25
NACRES:
NA.77
PubChem Substance ID:
329825968
UNSPSC Code:
12171501
MDL number:
MFCD29924807

主要文件

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InChI

1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)

SMILES string

ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1

InChI key

ABGOSOMRWSYAOB-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

A-196是SUV420H1和SUV420H2的一种有效且选择性的化学抑制剂，可抑制多种细胞系中H4K20me的二甲基和三甲基化。有关表征的完整详细信息，请访问结构基因组学联盟（SGC）网站上的 A-196 探针摘要 。

SGC2043是活性探针A-196的阴性对照。若需向SGC索要阴性对照样品，请 点击这里。

想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
A-196是SUV420H1和SUV420H2的一种有效和选择性化学抑制剂。

Features and Benefits

A-196是一种表观遗传化学探针，通过与Structural Genomics Consortium（SGC）合作获得。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。
该化合物是基因调控研究推荐产品。点击此处 ，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000173390
0000173391
0000173391
0000173390
0000107329

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Xin Cui et al.
JCI insight, 9(11) (2024-05-07)
Activation of brown adipose tissue (BAT) thermogenesis increases energy expenditure and alleviates obesity. Here we discover that histone methyltransferase suppressor of variegation 4-20 homolog 2 (Suv420h2) expression parallels that of Ucp1 in brown and beige adipocytes and that Suv420h2 knockdown
Alena Svobodová Kovaříková et al.
Cells, 9(2) (2020-02-09)
The DNA damage response is mediated by both DNA repair proteins and epigenetic markers. Here, we observe that N6-methyladenosine (m6A), a mark of the epitranscriptome, was common in RNAs accumulated at UV-damaged chromatin; however, inhibitors of RNA polymerases I and
Wendan Ren et al.
Nature communications, 12(1), 2490-2490 (2021-05-05)
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk. Here, we report that DNA
Dalia Rosano et al.
Cancer discovery, 14(5), 866-889 (2024-03-26)
Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic
Lenka Stixová et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 27(1-2), 41-55 (2019-01-06)
Repair of ribosomal DNA (rDNA) is a very important nuclear process due to the most active transcription of ribosomal genes. Proper repair of rDNA is required for physiological biogenesis of ribosomes. Here, we analyzed the epigenetics of the DNA damage
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