SML1569
Acotiamide dihydrochloride
≥98% (HPLC)
别名:
N-[2-[bis(1-Methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-Thiazolecarboxamide dihydrochloride, N-[2-[bis(1-Methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]thiazole-4-carboxamide dihydrochloride, YM-443 dihydrochloride, Z-338 dihydrochloride
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C21H30N4O5S · 2HCl
化学文摘社编号:
分子量:
523.47
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27)
SMILES string
CC(C)N(C(C)C)CCNC(C1=CSC(NC(C2=CC(OC)=C(OC)C=C2O)=O)=N1)=O.Cl[H]
InChI key
TWHZNAUBXFZMCA-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). Acotiamide showed no affinity for dopamine D2 or serotonin 5-HT4 receptors but does have activity as a muscarinic antagonist. It acts as a prokinetic drug through acetylcholinesterase inhibition and muscarinic receptor antagonism, and has been used for the treatment of functional dyspepsia (FD) involving gastric motility dysfunction.
Potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alkesh V Zala et al.
Expert opinion on emerging drugs, 20(2), 221-233 (2015-02-04)
Functional dyspepsia (FD) is a relatively common gastrointestinal clinical condition that remains poorly understood. Controversies remain regarding the definition, pathophysiology and optimum treatment. The current treatment of FD is limited and no established regimen is available. Recent advances have improved
K Ito et al.
Drug research, 66(4), 196-202 (2015-09-30)
Acotiamide is a first-in-class prokinetic drug approved in Japan for the treatment of functional dyspepsia. Given that acotiamide enhances gastric motility in conscious dogs and rats, we assessed the in vitro effects of this drug on the contraction of guinea
Norihisa Ishimura et al.
BMC gastroenterology, 15, 117-117 (2015-09-13)
The prevalence of gastroesophageal reflux disease (GERD) has been increasing worldwide, with proton pump inhibitor (PPI) administration the current mainstay therapy for affected individuals. However, PPI efficacy is insufficient especially for non-erosive reflux disease. Although it has been reported that
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持