SML1581
莫西沙星 盐酸盐
98.0 to 102.0% (HPLC)
别名:
12-8039, Avalox, BAY12-8039, 盐酸盐
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关于此项目
经验公式（希尔记法）:
C21H24FN3O4· HCl
化学文摘社编号:
分子量:
437.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
8377447
产品名称
莫西沙星 盐酸盐, 98-102% (HPLC)
InChI key
IDIIJJHBXUESQI-DFIJPDEKSA-N
SMILES string
Cl.COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(O)=O
InChI
1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1
assay
98-102% (HPLC)
form
powder
storage condition
desiccated
color
light yellow to yellow
solubility
H2O: slightly soluble
storage temp.
−20°C
Quality Level
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Application
盐酸莫西沙星已被用于研究其对已生长至高密度细菌的抗菌作用。
Biochem/physiol Actions
莫西沙星已被证明可有效治疗鼻窦炎、社区获得性呼吸道感染、肺炎和慢性支气管炎的急性加重。与其他氟喹诺酮（如环丙沙星和氧氟沙星）相比，它具有更好的抗革兰氏阳性活性。莫西沙星可用于治疗细菌性皮肤感染。它可以适当渗透到周围组织和炎性液体中。氟喹诺酮类可通过与酶-DNA复合物结合来稳定由DNA回旋酶和拓扑异构酶IV产生的DNA链断裂。 与哺乳动物DNA促旋酶相比，莫西沙星对细菌DNA促旋酶的亲和力高100倍。莫西沙星是一种抗生素，可抗革兰氏阳性和革兰氏阴性细菌。莫西沙星在治疗耐多药结核病中的研究正在进行中。
General description
莫西沙星是第四代合成氟喹诺酮类抗菌剂。莫西沙星与其他喹诺酮类药物不同，其是一种8-甲氧基喹诺酮。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
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