SML1594
西仑吉肽三氟乙酸盐
≥95% (HPLC), vascular targeting agent, powder
别名:
2,2,2-三氟乙酸, EMD 121974, NSC 707544, c(RGDF(NMe)V), 环(L-精氨酰甘氨酰-L-a-天冬氨酰-D-苯丙氨酰-N-甲基-L-缬氨酰), 2,2,2-三氟乙酸
产品名称
西仑吉肽三氟乙酸盐, ≥95% (HPLC)
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: 20 mg/mL, clear
储存温度
−20°C
SMILES字符串
N1([C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C1=O)Cc2ccccc2)CC(=O)O)CCCN\C(=N\[H])\N)C(C)C)C
InChI
1S/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1
InChI key
AMLYAMJWYAIXIA-VWNVYAMZSA-N
应用
西仑吉肽(cilengitide)的三氟乙酸盐已用作整合素αvβ5的抑制剂。
生化/生理作用
对多形性胶质母细胞瘤具有抗肿瘤活性。整合素是α和β链的异二聚体，作为跨膜受体负责细胞与细胞、细胞与胞外基质作用。可调控肿瘤血管生成、侵袭和迁移。
西仑吉肽(cilengitide)是可充当整合素拮抗剂的血管靶向制剂(VTA)。
西仑吉肽(cilengitide)是可充当整合素拮抗剂的血管靶向制剂(VTA)。 西仑吉肽是一种含Arg-Gly-Glu(RGD)的环状五肽，可选择性抑制整合素的αvβ3和αvβ5。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Activation of Hepatic Stellate Cells During Liver Carcinogenesis Requires Fibrinogen/Integrin αvβ5 in Zebrafish.
Yan C, et al.
Neoplasia, 20(5), 533-542 (2018)
Caroline Decourt et al.
Endocrinology, 164(2) (2022-12-13)
Timing of puberty requires exquisite coordination of genes, hormones, and brain circuitry. An increasing level of body adiposity, signaled to the brain via the fat-derived hormone leptin, is recognized as a major factor controlling puberty onset. However, it is clear
David A Reardon et al.
Expert opinion on investigational drugs, 17(8), 1225-1235 (2008-07-12)
Glioblastoma multiforme (GBM), a highly invasive and vascular cancer, responds poorly to conventional cytotoxic therapy. Integrins, widely expressed in GBM and tumor vasculature, mediate cell survival, migration and angiogenesis. Cilengitide is a potent alphavbeta3 and alphavbeta5 integrin inhibitor. To summarize
Marco A Alfonzo-Méndez et al.
Nature communications, 13(1), 905-905 (2022-02-18)
The crosstalk between growth factor and adhesion receptors is key for cell growth and migration. In pathological settings, these receptors are drivers of cancer. Yet, how growth and adhesion signals are spatially organized and integrated is poorly understood. Here we
David A Reardon et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(34), 5610-5617 (2008-11-05)
Cilengitide, an inhibitor of alphavbeta3 and alphavbeta5 integrin receptors, demonstrated minimal toxicity and durable activity across a wide range of doses administered to adults with recurrent glioblastoma multiforme (GBM) in a prior phase I study. The current multicenter phase II
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