SML1595
Luliconazole
≥98% (HPLC)
别名:
(αE)-α-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile, NND 502, [R-(E)]-α-[4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile
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选择尺寸
关于此项目
经验公式（希尔记法）:
C14H9Cl2N3S2
化学文摘社编号:
分子量:
354.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
SMILES string
N#C/C(N1C=NC=C1)=C2SC[C@@H](C3=C(Cl)C=C(Cl)C=C3)S/2
InChI key
YTAOBBFIOAEMLL-REQDGWNSSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
General description
Luliconazole also called LLCZ, {(−)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl) acetonitrile} is optically active compound. It is used as a topical medicine for treating dermatophytosis and dermatitis. It is a potential antifungal against Candida and other fungal infections of skin, groin and feet.
Biochem/physiol Actions
Luliconazole is an imidazole antifungal.
Luliconazole is an imidazole antifungal. Its mechanism of action involves inhibition of ergosterol biosynthesis by inhibition of sterol 14α-demethylase.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
In vitro antifungal activities of luliconazole, a new topical imidazole
Koga H, et al.
Medical Mycology, 47(6), 640-647 (2009)
A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections
Gupta AK and Daigle D
Infection and Drug Resistance, 9(6), 1-6 (2016)
Short-term therapy with luliconazole, a novel topical antifungal imidazole, in guinea pig models of tinea corporis and tinea pedis
Koga H, et al.
Antimicrobial Agents and Chemotherapy, AAC-05255 (2012)
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