SML1600
Rinvanil
≥98% (HPLC)
别名:
(9Z,12R)-12-Hydroxy-N-[(4-hydroxy-3-methoxyphenyl)methyl]-9-octadecenamide, N-Vanillylricinoleamide
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Assay:
≥98% (HPLC)
Form:
oil
Biochem/physiol Actions
Rinvanil is a Capsaicin analogue that potently activates transient receptor potential vanilloid 1 (TRPV1) channels.
Rinvanil is a Capsaicin analogue that potently activates transient receptor potential vanilloid 1 (TRPV1) channels. Rinvanil induces neuroprotective mild hypothermia in ischemic brain injured mice through TRPV1 activation. Rinvanil exhibits potent anticancer activity in cancer cell lines including cervical (HeLa, CaSKi, ViBo) and leukemia (P388, J774, WEHI-3) cell lines. Rinvanil is not cytotoxic to normal lymphocytes.
TRPV1 (transient receptor potential vanilloid 1) is a capsaicin receptor. It is strongly expressed in sensory neurons and participates in pain perception. In brain, it regulates neuronal function, motor behaviour and neuroinflammation. Capsaicin plays an important role in the activation of TRPV1.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable