Besifloxacin hydrochloride

Name: Besifloxacin hydrochloride
Brand: SIGMA

≥98% (HPLC)

别名:

7-[-3-Aminoazepam-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₉H₂₁ClFN₃O₃ · HCl

CAS Number:

1398566-43-2

分子量:

430.30

MDL编号:

MFCD23712955

UNSPSC代码:

12352200

PubChem化学物质编号:

329825494

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to light brown

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

−20°C

SMILES字符串

[H]Cl.OC(C1=CN(C2CC2)C3=C(Cl)C(N4CCCCC(N)C4)=C(F)C=C3C1=O)=O

InChI

1S/C19H21ClFN3O3.ClH/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23;/h7,9-11H,1-6,8,22H2,(H,26,27);1H

InChI key

PMQBICKXAAKXAY-UHFFFAOYSA-N

生化/生理作用

Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic.

Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic. Besifloxacin is effective against gram positive and negative, aerobic and anerobic bacteria. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex generating persistent, covalent enzyme–DNA adducts, inhibiting DNA synthesis. Besifloxacin inhibits both DNA gyrase and topoisomerase IV at nearly equal concentrations. It is used clinically primarily in the treatment of bacterial conjunctivitis.

Besifloxacin stops the production of pro-inflammatory cytokines in vitro.