SML1625

Gemifloxacin mesylate

Name: Gemifloxacin mesylate
Brand: SIGMA

≥98% (HPLC)

别名:

7-(4-Aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1,8-naphthyridine-3-carboxylic acid mesylate, 7-[(4Z)-3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid monomethanesulfonate

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₀FN₅O₄ · CH₄O₃S

化学文摘社编号:

210353-53-0

分子量:

485.49

NACRES:

NA.77

PubChem Substance ID:

329825509

UNSPSC Code:

12352200

MDL number:

MFCD08277637

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color

white to light brown

InChI key

JIYMVSQRGZEYAX-CWUUNJJBSA-N

SMILES string

CS(=O)(O)=O.OC(C1=CN(C2CC2)C3=NC(N4C/C(C(CN)C4)=N\OC)=C(F)C=C3C1=O)=O

InChI

1S/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27);1H3,(H,2,3,4)/b22-14+;

assay

≥98% (HPLC)

form

powder

solubility

H₂O: 10 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

Gemifloxacin is a broad-spectrum quinolone antibacterial.

Gemifloxacin is a broad-spectrum quinolone antibacterial. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex generating persistent, covalent enzyme–DNA adducts, inhibiting DNA synthesis. Gemifloxacin is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. Gemifloxacin has also been found to inhibit migration and invasion of human colon cancer cells.