SML1638
VX-745
≥98% (HPLC)
别名:
5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式(希尔记法):
C19H9Cl2F2N3OS
化学文摘社编号:
分子量:
436.26
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
FC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1
InChI
1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChI key
VEPKQEUBKLEPRA-UHFFFAOYSA-N
基因信息
human ... MAPK14(1432)
相关类别
生化/生理作用
VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα.
VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.
其他说明
VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Xiaodong Chen et al.
Journal of cancer research and clinical oncology, 145(6), 1471-1484 (2019-04-26)
To study an association between IL-6 signaling and resistance to radiotherapy of prostate cancer (PCa) and explore the molecular mechanisms involved. IL-6 expressing C4-2 and CWR22Rv1 (C4-2IL-6/CWRIL-6) and vector control (C4-2vec/CWRvec) cell lines were developed. Radiation-sensitivities of these cells were
Mehdi Bouhaddou et al.
Cell, 182(3), 685-712 (2020-07-10)
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持