SML1642
DHED
≥98% (HPLC)
别名:
(17β)-10,17-二羟基-雌甾--1,4-二烯-3-酮, 10β,17β-二羟基雌甾-1,4-二烯-3-酮, 3,16-二羟基雄甾-5-烯-17,19-二酮
产品名称
DHED, ≥98% (HPLC)
SMILES string
O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=CC(C=C1)=O
InChI
1S/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h6,9-10,13-16,20-21H,2-5,7-8H2,1H3/t13-,14-,15-,16-,17-,18+/m0/s1
InChI key
UIKDFTLKOKNUJP-UGDFAFBOSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -20 to -30°, c = 1 in methanol
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
DHED已被用来诱导帕金森′病（PD）样运动综合征3K转基因小鼠中雌激素水平的增加。
Biochem/physiol Actions
DHED 是一种无活性的前药，仅在大脑中选择性地产生雌激素。
DHED是烟酰胺腺嘌呤二核苷酸磷酸（NADPH）依赖性脱氢酶/还原酶的底物。它在大脑中的表达与神经保护功能有关。
DHED（10β,17β-dihydroxyestra-1,4-dien-3-one）是一种无活性的前药，仅在大脑中选择性地产生雌激素。 DHED 通过仅在 CNS 中表达的酶在大脑中转化为 17β-雌二醇，但在身体的其余部分呈惰性。 研究发现 DHED 可在大鼠中风模型中具有神经保护作用，并逆转雌激素缺乏的神经系统症状，例如缺乏卵巢的雌性大鼠的记忆问题。
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Molly M Rajsombath et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(38), 7628-7640 (2019-08-14)
Many studies report a higher risk for Parkinson's disease (PD) and younger age of onset in men. This, and the fact that the neuropathological process underlying PD symptoms may begin before menopause, suggests that estrogen-based hormone therapy could modify this
Laszlo Prokai et al.
Science translational medicine, 7(297), 297ra113-297ra113 (2015-07-24)
Many neurological and psychiatric maladies originate from the deprivation of the human brain from estrogens. However, current hormone therapies cannot be used safely to treat these conditions commonly associated with menopause because of detrimental side effects in the periphery. The
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