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SML1644

MRT68921 二盐酸盐

≥98% (HPLC)

别名:

N- [3-[[5-环丙基-2-[（1,2,3,4-四氢-2-甲基-6-异喹啉基）氨基] -4-嘧啶基]氨基]丙基]-环丁烷甲酰胺 二盐酸盐

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关于此项目

经验公式（希尔记法）:
C25H34N6O · 2HCl
化学文摘社编号:
1190379-70-4
分子量:
507.50
UNSPSC Code:
12352200
PubChem Substance ID:
329825985
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C1)CCC2=C1C=CC(NC3=NC=C(C4CC4)C(NCCCNC(C5CCC5)=O)=N3)=C2.[H]Cl.[H]Cl

InChI

1S/C25H34N6O.2ClH/c1-31-13-10-19-14-21(9-8-20(19)16-31)29-25-28-15-22(17-6-7-17)23(30-25)26-11-3-12-27-24(32)18-4-2-5-18;;/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H,27,32)(H2,26,28,29,30);2*1H

InChI key

NLKPLTWKINJHCK-UHFFFAOYSA-N

Application

MRT68921二盐酸盐的应用：
  • 作为SH-SY5Y神经母细胞瘤细胞中Unc-51样激酶1(ULK1)的抑制剂
  • 作为肝内淋巴细胞中ULK1和ULK2激酶的抑制剂
  • 检测其作为ULK1抑制剂，对泛素特异性肽酶24(USP24)敲低人神经胶质瘤H4细胞中自噬体积聚的缓解作用

Biochem/physiol Actions

MRT68921 是体外 ULK1 和 ULK2 激酶的细胞渗透的、高效和特异性抑制剂。
MRT68921 是体外 ULK1 和 ULK2 激酶的细胞渗透的、高效和特异性抑制剂，可降低细胞中 ULK1 的活性并阻止自噬诱导。MRT68921 阻断 mTOR 依赖性自噬。
MRT68921具有细胞毒性，通过作用于氧化应激信号而杀死癌细胞，是一种有效的肿瘤治疗药物。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000160013
0000160013
0000121697
0000121698
0000078261

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