SML1681
Endosidin2
≥98% (HPLC), EXO70 Inhibitor, powder
别名:
(E)-3-Fluoro-N′-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide
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关于此项目
经验公式（希尔记法）:
C15H12FIN2O3
化学文摘社编号:
分子量:
414.17
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Endosidin2, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
FC1=CC(C(N/N=C/C2=CC(OC)=C(O)C(I)=C2)=O)=CC=C1
InChI
1S/C15H12FIN2O3/c1-22-13-6-9(5-12(17)14(13)20)8-18-19-15(21)10-3-2-4-11(16)7-10/h2-8,20H,1H3,(H,19,21)/b18-8+
InChI key
UIADDCURKKFTFW-QGMBQPNBSA-N
生化/生理作用
Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd = 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.
Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex and reduces exocytosis and endosomal recycling in plant and mammalian cells.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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