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Merck
CN

SML1695

RSV604

≥98% (HPLC)

别名:

(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea, RSV-604

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关于此项目

经验公式（希尔记法）:
C22H17FN4O2
化学文摘社编号:
676128-63-5
分子量:
388.39
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD28963952
Assay:
≥98% (HPLC)
Form:
film
Quality level:
100
Storage condition:
protect from light

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产品名称

RSV604, ≥98% (HPLC)

InChI key

MTPVBMVUENFFLL-HXUWFJFHSA-N

SMILES string

O=C(N1)[C@@H](NC(NC2=CC=CC=C2F)=O)N=C(C3=CC=CC=C3)C4=C1C=CC=C4

assay

≥98% (HPLC)

form

film

storage condition

protect from light

color

white

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

RSV604 (RSV-604) is a cell-permeable, non-cytotoxic benzodiazepine derivative that is reported to target respiratory syncytial virus (RSV) nucleoprotein (N) via affinity interaction.
RSV604 (RSV-604) is a cell-permeable, non-cytotoxic (CC50 >50 μM) benzodiazepine derivative that is reported to target respiratory syncytial virus (RSV) nucleoprotein (N) via affinity interaction (Kd = 134 μM) and display similar antiviral potency against 40 clinical human RSV isolates (Ave. EC50 = 800 nM), including both subtypes A and B. Although RSV604 displays host-dependent potency against RSV cellular replication (EC50 = 2 μM/HeLa, 1.8 μM/HEp-2, >50 μM/BHK-21 based on cellular viral F protein level 72 hrs post RSV A2 infection) and release (by >1,000,000-fold/HeLa vs. no effect/BHK-21 72 hrs post infection; [RSV604] = EC90), complete loss of infectivity of released RSV from RSV604-treated cells is observed in both HeLa and BHK-21 cultures. RSV604 is also active against bovine RSV, but inactive toward mouse pneumonia virus, human metapneumovirus or parainfluenza virus types 1 &3 (PIV1 &PIV3).

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
106M4723V

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Yuzhen Gao et al.
Molecules (Basel, Switzerland), 26(9) (2021-05-06)
Respiratory syncytial virus (RSV) is a major pathogen that causes severe lower respiratory tract infection in infants, the elderly and the immunocompromised worldwide. At present no approved specific drugs or vaccines are available to treat this pathogen. Recently, several promising

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