SML1707
替莫泊芬
≥90% (HPLC)
别名:
3,3′,3′′,3′′′-(7,8-二氢-21H，23H-吗啡-5,10,15,20-四基）四酚, 5,10,15,20-四（间羟基苯）氯
产品名称
替莫泊芬, ≥90% (HPLC)
storage temp.
−20°C
Quality Level
InChI
1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2
InChI key
LYPFDBRUNKHDGX-UHFFFAOYSA-N
assay
≥90% (HPLC)
form
powder
color
dark brown to black
solubility
DMSO: 2 mg/mL, clear (warmed)
Biochem/physiol Actions
替莫卟吩是用于光动力疗法的光敏剂。
替莫卟吩是用于光动力疗法的光敏剂。 替莫卟吩已在临床上用于治疗晚期头颈部鳞状细胞癌，并且正在研究用于其他几种癌症。
General description
替莫卟吩/（四[间羟基苯基]二氢卟酚，m-THPC）是疏水性第二代光敏剂。通过光动力疗法用于晚期头颈癌患者的姑息治疗。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Amandine Pinto et al.
ACS nano, 15(2), 3251-3263 (2021-01-23)
The dissemination of tumor metastasis in the peritoneal cavity, also called peritoneal metastasis (PM) or carcinomatosis, represents a late stage of gastrointestinal and gynecological cancer with very poor prognosis, even when cytoreductive surgery is effective, due to residual microscopic disease.
Temoporfin-loaded liposomes: physicochemical characterization
Kuntsche J, et al.
European Journal of Pharmaceutical Sciences, 40(4), 305-315 (2010)
Distribution of temoporfin, a new photosensitizer for the photodynamic therapy of cancer, in a murine tumor model
Whelpton R, et al.
Photochemistry and Photobiology, 61(4), 397-401 (1995)
T Hauge et al.
Photodiagnosis and photodynamic therapy, 13, 330-333 (2015-09-30)
Photodynamic therapy (PDT) in combination with stent have shown promising results in the treatment of biliary tract cancer (BTC) in patients not suitable for surgery. Chemotherapy has been shown to improve survival in patients with local advanced and metastatic BTC.
Andrej Wagner et al.
Hepatology (Baltimore, Md.), 62(5), 1456-1465 (2015-05-21)
Photodynamic therapy using porfimer (P-PDT) improves palliation and survival in nonresectable hilar bile duct cancer. Tumoricidal penetration depth of temoporfin-PDT (T-PDT) is twice that of P-PDT. In a single-arm phase II study we investigated the safety, efficacy, survival time, and
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