SML1711
TNCA
≥98% (HPLC)
别名:
(3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, Lycoperodine-1
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关于此项目
经验公式（希尔记法）:
C12H12N2O2
化学文摘社编号:
分子量:
216.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
TNCA, ≥98% (HPLC)
InChI
1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
SMILES string
O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
InChI key
FSNCEEGOMTYXKY-JTQLQIEISA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
color
white to beige
solubility
1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity.
TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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