SML1714
DCAI
≥95% (HPLC)
别名:
2-(4,6-Dichloro-2-methyl-1h-indol-3-yl)ethanamine, 4,6-Dichloro-2-methyl-3-aminoethylindole
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关于此项目
经验公式（希尔记法）:
C11H12Cl2N2
CAS Number:
分子量:
243.13
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to brown
溶解性
DMSO: 20 mg/mL, clear
储存温度
−20°C
SMILES字符串
Clc1c2c([nH]c(c2CCN)C)cc(c1)Cl
InChI
1S/C11H12Cl2N2/c1-6-8(2-3-14)11-9(13)4-7(12)5-10(11)15-6/h4-5,15H,2-3,14H2,1H3
InChI key
JCTJISIFGZHOFY-UHFFFAOYSA-N
相关类别
生化/生理作用
DCAI, an Inactive Ras, is bound to a GDP and activated by SOS (son of sevenless, among others), which converts it to the active GTP form. DCAI is a known binder to Ras, which inhibits SOS nucleotide exchange, inhibiting Ras activation.
DCAI, an inactive Ras, is bound to a GDP and activated by SOS (son of sevenless, among others) which converts it to the active GTP form.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jon J G Winter et al.
Journal of medicinal chemistry, 58(5), 2265-2274 (2015-02-20)
Constitutively active mutant KRas displays a reduced rate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resulting in the perpetual activation of Ras pathways. We describe a fragment screening campaign using X-ray crystallography that led to the discovery
Till Maurer et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(14), 5299-5304 (2012-03-21)
The Ras gene is frequently mutated in cancer, and mutant Ras drives tumorigenesis. Although Ras is a central oncogene, small molecules that bind to Ras in a well-defined manner and exert inhibitory effects have not been uncovered to date. Through
Thi B Trinh et al.
ACS combinatorial science, 18(1), 75-85 (2015-12-10)
Cyclic peptides have great potential as therapeutic agents and research tools. However, their applications against intracellular targets have been limited, because cyclic peptides are generally impermeable to the cell membrane. It was previously shown that fusion of cyclic peptides with
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