SML1766
双叶茶素
≥98% (HPLC)
别名:
9-（1,3-苯并二恶唑-5-基）-4-羟基-6,7-二甲氧基萘[2,3-c]呋喃-1（3H）-酮, NSC 309691
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经验公式（希尔记法）:
C21H16O7
化学文摘社编号:
分子量:
380.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
双叶茶素, ≥98% (HPLC)
InChI
1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3
SMILES string
OC1=C2C(C(OC2)=O)=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C51
InChI key
VMEJANRODATDOF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
相关类别
Application
山荷叶素已用于研究其对鱼类病原体的抗菌和抗生物膜活性。
Biochem/physiol Actions
山荷叶素是一种天然的芳基萘，具有强大的抗癌和抗病毒活性。
山荷叶素是一种天然的芳基萘，具有强大的抗癌和抗病毒活性。它是液泡中H（+）-ATPase（V-ATPase）的强效抑制剂，可抑制破骨细胞中的溶酶体酸化。
山荷叶素有望用于以过度再吸收为特征的骨骼问题的新型治疗方法。
General description
山荷叶素是一种主要的糖苷化合物，它是一种来源于植物的木脂素。它存在于 丘生闭花木 ( Cleistanthus collinus)中。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhitao Zhang et al.
European journal of medicinal chemistry, 82, 466-471 (2014-06-16)
The concise syntheses of two natural diphyllin glycosides Cleistanthin-A (CA), Cleistanthoside-A (CleA) and its derivative, Cleistanthoside-A tetraacetate (CleT), have been achieved. They were evaluated for their in vitro anti-proliferative activities against MCF-7, HeLa, HepG2, HCT-116, U251 cancer cell lines by
Mette G Sørensen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 22(10), 1640-1648 (2007-06-20)
Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds
Suman Thamburaj et al.
Microbial pathogenesis, 145, 104232-104232 (2020-05-01)
Annihilation of biofilm forming bacterial pathogens is a challenging aspect in seafood and aquaculture industries. Microbes growing as biofilms cause deleterious effects on food products leading to food spoilage or loss of shelf life. As a measure to fight biofilms
Yapeng Lu et al.
European journal of pharmacology, 771, 130-138 (2015-12-23)
The vacuolar H(+)-ATPase (V-ATPase) has recently been proposed as a key target for new strategies in cancer treatment. Our previous work has proved that diphyllin glycoside is a novel inhibitor of V-ATPase. Here the cytotoxic effects of ZT-25, the most
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