SML1767
荆三棱中新化合物Sparstolonin B
≥98% (HPLC)
别名:
4,10-二羟基-3H-吡喃[3,4,5-kl] 呫吨-3-酮, SsnB, 天然药物Sparstolenin B
InChI
1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H
InChI key
DHSASSJDMAHICE-UHFFFAOYSA-N
SMILES string
OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
Sparstolonin B（SsnB）是一种从黑三棱和荆三棱中分离得到的异香豆素，是一种有效的TLR2和TLR4拮抗剂，具有抗炎和抗病毒（抗HIV）特性。Sparstolonin B在3T3- L1脂肪细胞中可抑制LPS诱导的炎症，并降低高脂饮食喂养的大鼠体重。Sparstolonin B可减轻小鼠模型中非酒精性脂肪性肝炎（NASH）的炎症。
Sparstolonin B（SsnB）是一种多酚。它具有类似于氧杂蒽酮和异香豆素的结构特征。 SsnB对小鼠和人类巨噬细胞具有抗炎效果。 SsnB可通过阻断细胞外信号调节蛋白激酶（ERK1/2）和c-jun N端激酶（JNK）信号通路而显著降低缺氧-再氧合诱导的心肌炎。因此，SsnB可作为治疗心肌缺血再灌注（MIR）损伤的一种有效疗法。
具有抗炎和抗病毒（抗HIV）特性的有效TLR2和TLR4拮抗剂
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation
Liu Q, et al.
Exp. Biol. Med, 239(3), 376-384 (2014)
Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties.
Liang Q, et al.
The Journal of Biological Chemistry, 286(30), 26470-26479 (2011)
Diptadip Dattaroy et al.
American journal of physiology. Gastrointestinal and liver physiology, 310(7), G510-G525 (2016-01-01)
Although significant research data exist on the pathophysiology of nonalcoholic steatohepatitis (NASH), finding an efficient treatment regimen for it remains elusive. The present study used sparstolonin B (SsnB), a novel TLR4 antagonist derived from the Chinese herb Sparganium stoloniferum, as
Xin Deng et al.
Virology journal, 12, 108-108 (2015-07-25)
The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection. We found that SsnB treatment blocked
Ming Wang et al.
European journal of pharmacology, 769, 79-85 (2015-11-03)
Sparstolonin B (SsnB), an isocoumarin compound isolated from the tubers of both Sparganium stoloniferum and Scirpus yagara, has been reported to have anti-inflammatory effects. However, whether SsnB has anti-inflammatory effects on LPS-stimulated 3T3-L1 adipocytes remains unclear. In this study, we
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