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Merck
CN

SML1772

Givinostat hydrochloride hydrate

≥95% (HPLC), HDAC inhibitor, powder

别名:

Diethyl-[6-(4-hydroxycarbamoyl-phenyl carbamoyloxymethyl)-naphthalen-2-yl methyl]-ammonium chloride, ITF2357, N-[4-[(Hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride

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关于此项目

经验公式（希尔记法）:
C24H27N3O4 · HCl · H2O
化学文摘社编号:
732302-99-7
分子量:
475.97
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD18385007
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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产品名称

Givinostat hydrochloride hydrate, ≥95% (HPLC)

InChI

1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2

SMILES string

[H]Cl.[H]O[H].CCN(CC)CC1=CC=C(C=C(COC(NC2=CC=C(C(NO)=O)C=C2)=O)C=C3)C3=C1

InChI key

FKGKZBBDJSKCIS-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

相关类别

Application

Givinostat hydrochloride hydrate has been used as a histone deacetylase inhibitor to test its effect on the human immunodeficiency virus reactivation in CD4+ T-cell model.

Biochem/physiol Actions

Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes.
Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas).
Givinostat is known to mediate the reduction of the human immunodeficiency virus release in macrophages.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000527825
0000527825
0000522566
0000522566
0000499292

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Francesca Curreli et al.
Viruses, 12(6) (2020-06-07)
Combination antiretroviral therapy (cART) is successful in maintaining undetectable levels of HIV in the blood; however, the persistence of latent HIV reservoirs has become the major barrier for a HIV cure. Substantial efforts are underway in finding the best latency-reversing

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