SML1791
尿石素A
≥97% (HPLC), powder, anti-inflammatory
别名:
3,8-二羟基-6H-苯并[c]苯并吡喃-6-酮
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关于此项目
经验公式（希尔记法）:
C13H8O4
化学文摘社编号:
分子量:
228.20
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
尿石素A, ≥97% (HPLC)
InChI
1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
SMILES string
OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
InChI key
RIUPLDUFZCXCHM-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
尿石素A已用于：
- 通过体外细胞增殖实验检测其对白血病细胞系的抗白血病作用
- 作为线粒体自噬激活剂，研究缺血再灌注(I/R)损伤时，磷酸甘油酸变位酶5(PGAM5)表达对线粒体自噬细胞死亡的影响
- 研究其经由P53-Mdm2-Snail通路对肺癌细胞上皮间质转化(EMT)的抑制作用
- 研究其激活沉默交配型信息调节因子2同源蛋白1(sirtuin 1/silent mating type information regulation 2 homolog 1, SIRT1)信号通路，对链脲菌素诱导的大鼠糖尿病性心肌病的影响作用
Biochem/physiol Actions
尿石素A是一种具有抗增殖和抗氧化活性的天然产物。
尿石素A是一种具有抗增殖和抗氧化活性的天然产物。尿石素A是由一些坚果和水果中的多酚代谢形成的，尤其是石榴。尿石素A已被证明可穿过血脑屏障，并可能对阿尔茨海默病具有神经保护作用。
尿石素A是研究最为充分的尿石素，具有抗炎和抗肥胖效用。也可抑制结肠癌、前列腺癌和膀胱癌等多种癌症的发生发展，作用机制是下调多种癌基因，包括哺乳动物雷帕霉素靶蛋白(mTOR)和Kirsten大鼠肉瘤病毒癌基因(K-Ras)，并上调肿瘤抑制基因，包括p53和表皮生长因子受体(EGFR)，从而影响多条肿瘤信号通路。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Abdulaziz Musa Alzahrani et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and
Yun Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1107-1115 (2015-04-26)
The intestinal metabolites of ellagic acid (EA), urolithins are known to effectively inhibit cancer cell proliferation. This study investigates antiproliferative and antioxidant effects of urolithin A (UA) on cell survival of the HepG2 hepatic carcinomas cell line. The antiproliferative effects
Tao Yuan et al.
ACS chemical neuroscience, 7(1), 26-33 (2015-11-13)
Pomegranate shows neuroprotective effects against Alzheimer's disease (AD) in several reported animal studies. However, whether its constituent ellagitannins and/or their physiologically relevant gut microbiota-derived metabolites, namely, urolithins (6H-dibenzo[b,d]pyran-6-one derivatives), are the responsible bioactive constituents is unknown. Therefore, from a pomegranate
Gadah Albasher et al.
Saudi journal of biological sciences, 29(2), 1210-1220 (2022-03-05)
This study examined the cardiac anti-cardiomyopathy (DC) protective effect of urolithin A in streptozotocin (STZ)-treated rats and investigated if this protection involves activation of SIRT1 signaling. Diabetes was induced first STZ (65 mg/kg, i.p.) before starting the experiments. Adult male rats
Abdulaziz Musa Alzahrani et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and
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