SML1791
尿石素A
≥97% (HPLC), powder, anti-inflammatory
别名:
3,8-二羟基-6H-苯并[c]苯并吡喃-6-酮
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关于此项目
经验公式（希尔记法）:
C13H8O4
化学文摘社编号:
分子量:
228.20
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
尿石素A, ≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
InChI
1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
InChI key
RIUPLDUFZCXCHM-UHFFFAOYSA-N
Application
尿石素A已用于：
- 通过体外细胞增殖实验检测其对白血病细胞系的抗白血病作用
- 作为线粒体自噬激活剂，研究缺血再灌注(I/R)损伤时，磷酸甘油酸变位酶5(PGAM5)表达对线粒体自噬细胞死亡的影响
- 研究其经由P53-Mdm2-Snail通路对肺癌细胞上皮间质转化(EMT)的抑制作用
- 研究其激活沉默交配型信息调节因子2同源蛋白1(sirtuin 1/silent mating type information regulation 2 homolog 1, SIRT1)信号通路，对链脲菌素诱导的大鼠糖尿病性心肌病的影响作用
Biochem/physiol Actions
尿石素A是一种具有抗增殖和抗氧化活性的天然产物。
尿石素A是一种具有抗增殖和抗氧化活性的天然产物。尿石素A是由一些坚果和水果中的多酚代谢形成的，尤其是石榴。尿石素A已被证明可穿过血脑屏障，并可能对阿尔茨海默病具有神经保护作用。
尿石素A是研究最为充分的尿石素，具有抗炎和抗肥胖效用。也可抑制结肠癌、前列腺癌和膀胱癌等多种癌症的发生发展，作用机制是下调多种癌基因，包括哺乳动物雷帕霉素靶蛋白(mTOR)和Kirsten大鼠肉瘤病毒癌基因(K-Ras)，并上调肿瘤抑制基因，包括p53和表皮生长因子受体(EGFR)，从而影响多条肿瘤信号通路。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Sheng-Long Ding et al.
Journal of inflammation (London, England), 17, 13-13 (2020-03-27)
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory properties
Antonio González-Sarrías et al.
European journal of nutrition, 56(2), 831-841 (2015-12-19)
Urolithins, metabolites produced by the gut microbiota from ellagic acid, have been acknowledged with cancer chemopreventive activity. Although urolithin A (Uro-A) has been reported to be the most active one, 10-50 % of humans can also produce the isomer isourolithin A
Yun Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1107-1115 (2015-04-26)
The intestinal metabolites of ellagic acid (EA), urolithins are known to effectively inhibit cancer cell proliferation. This study investigates antiproliferative and antioxidant effects of urolithin A (UA) on cell survival of the HepG2 hepatic carcinomas cell line. The antiproliferative effects
Tao Yuan et al.
ACS chemical neuroscience, 7(1), 26-33 (2015-11-13)
Pomegranate shows neuroprotective effects against Alzheimer's disease (AD) in several reported animal studies. However, whether its constituent ellagitannins and/or their physiologically relevant gut microbiota-derived metabolites, namely, urolithins (6H-dibenzo[b,d]pyran-6-one derivatives), are the responsible bioactive constituents is unknown. Therefore, from a pomegranate
Hang Zhu et al.
Redox biology, 38, 101777-101777 (2020-11-10)
The death of cardiomyocytes either through apoptosis or necroptosis is the pathological feature of cardiac ischemia-reperfusion (I/R) injury. Phosphoglycerate mutase 5 (PGAM5), a mitochondrially-localized serine/threonine-protein phosphatase, functions as a novel inducer of necroptosis. However, intense debate exists regarding the effect
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1791-5MG | 04061832275666 |
| SML1791-25MG | 04061832275659 |
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