SML1795
替诺福韦
≥98% (HPLC), DNA chain terminator, powder
别名:
(R)-9-(2-膦酰乙氧基丙基)腺嘌呤, (R)-PMPA
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关于此项目
经验公式（希尔记法）:
C9H14N5O4P
化学文摘社编号:
分子量:
287.21
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
替诺福韦, ≥98% (HPLC)
SMILES string
OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O
InChI
1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
InChI key
SGOIRFVFHAKUTI-ZCFIWIBFSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -20 to -26°, c = 0.5 in 1 M HCl
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
替诺福韦是一种核苷酸类似物逆转录酶抑制剂（nRTI），可导致DNA转录过早终止。
替诺福韦是一种核苷酸类似物逆转录酶抑制剂（nRTI），可导致DNA转录过早终止。替诺福韦是一种用于HIV治疗和预防的抗逆转录病毒药物。
替诺福韦的口服生物利用度较低。因此，它可以作为称为替诺福韦地索普西富马酸盐的前药。一旦摄入，替诺福韦地索普西富马酸盐可被水解成替诺福韦并被磷酸化。然后将其掺入病毒DNA中，导致链终止。替诺福韦对乙型肝炎病毒也有效。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Courtney Sakolish et al.
Drug metabolism and disposition: the biological fate of chemicals (2024-04-17)
In vitro models that can faithfully replicate critical aspects of kidney tubule function such as directional drug transport are in high demand in pharmacology and toxicology. Accordingly, development and validation of new models is underway. The objective of this study
B L Robbins et al.
Antimicrobial agents and chemotherapy, 42(3), 612-617 (1998-03-28)
Bis(isopropyloxymethylcarbonyl) 9-R-(2-phosphonomethoxypropyl)adenine [bis(POC)PMPA] has been identified as a novel prodrug of PMPA. The anti-human immunodeficiency virus activity of bis(POC)PMPA was >100-fold greater than that of PMPA in both an established T-cell line and primary peripheral blood lymphocytes. This improved efficacy
Kevin R Robertson et al.
AIDS (London, England), 30(15), 2315-2321 (2016-06-23)
The objective was to determine whether maraviroc (MVC) has unique neurocognitive benefits in the context of initial antiretroviral therapy (ART). Randomized, double-blind, placebo-controlled, 48-week trial. Participants were enrolled in US AIDS Clinical Trials Group clinical trial sites. Total 262 ART-naive
Tracy P Trang et al.
Expert opinion on drug safety, 15(9), 1287-1294 (2016-07-09)
Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors approved as pre-exposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). Prophylactic TDF-based regimens have been shown to reduce the risk of HIV infection by 74 to 92% among
Setjie W Maepa et al.
Bio-protocol, 14(15), e5042-e5042 (2024-08-12)
The liver is an essential organ that is involved in the metabolism, synthesis, and secretion of serum proteins and detoxification of xenobiotic compounds and alcohol. Studies on liver diseases have largely relied on cancer-derived cell lines that have proven to
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