SML1807
SB-258719
≥98% (HPLC)
别名:
N，3-二甲基-N-[（（1R）-1-甲基-3-（4-甲基-1-哌啶基）丙基]苯磺酰胺, SB 258719
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H30N2O2S
化学文摘社编号:
分子量:
338.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3
SMILES string
CC1=CC=CC(S(N(C)[C@H](C)CCN2CCC(C)CC2)(=O)=O)=C1
InChI key
AGVNHDNTFYHZNL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
oil
color
off-white to brown
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
SB-258719 是一种选择性和有效的 5-HT7 拮抗剂。SB-258719 逆转了 5-CT 对小鼠的低温作用。
选择性和有效的 5-HT7 拮抗剂
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
D R Thomas et al.
British journal of pharmacology, 124(6), 1300-1306 (1998-08-28)
1. The functional profile of the long form of the human cloned 5-HT7 receptor (designated h5-HT7(a)) was investigated using a number of 5-HT receptor agonists and antagonists and compared with its binding profile. Receptor function was measured using adenylyl cyclase
Xin Zhao et al.
Scientific reports, 5, 9043-9043 (2015-03-13)
Fisetin, a natural flavonoid, has been shown in our previous studies to exert antidepressant-like effect. As antidepressant drugs are clinically used to treat chronic neuropathic pain, this work aimed to investigate the potential antinociceptive efficacies of fisetin against neuropathic pain
Sarwat Fatima et al.
Molecular oncology, 10(2), 195-212 (2015-10-18)
5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling is highly dysregulated in a majority of HCC, this study explored
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