SML1812
IMR-1
≥98% (HPLC)
别名:
2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester, Inhibitor of Mastermind Recruitment-1
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关于此项目
经验公式（希尔记法）:
C15H15NO5S2
化学文摘社编号:
分子量:
353.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
InChI
1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)
InChI key
QHPJWPQRZMBKTG-UHFFFAOYSA-N
SMILES string
O=C(OCC)COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
Inhibitor of mastermind recruitment-1 (IMR-1) has been used as an inhibitor of Notch transcription activation complex to downregulate the expression of Notch and downstream protein in pheochromocytoma (PC -12) cells.
Biochem/physiol Actions
IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A.
IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ruiting Liu et al.
International journal of clinical and experimental pathology, 11(1), 99-109 (2018-01-01)
Background: Parkinson's disease (PD) is a degenerative disease of central nervous system. 1-Methyl-4-phenylpyridine (MPP+) is a non-selective dopaminergic neurotoxin that induces cell injury similar to PD. This study aimed to explore the protective effects of Radix Ophiopogonis polysaccharide extracts (ROP)
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