Merck
CN

SML1822

Sigma-Aldrich

木通皂苷 PK

≥98% (HPLC)

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别名:
3-O-α-L-阿拉伯吡喃糖基二十二碳四烯酸-28-β-D-吡喃葡萄糖苷-(1→6)-β-D-吡喃葡萄糖苷, ASD, 曲霉皂甙VI, 牛磺苷St-G0-1, 蕾叶木苷A
Empirical Formula (Hill Notation):
C47H76O18
CAS号:
分子量:
929.10

生物来源

(Dipsacus asper)

质量水平

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D +13 to +18°, c = 0.5 in methanol

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 3 mg/mL, clear (warmed)

运输

wet ice

储存温度

−20°C

SMILES string

CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]5(C)[C@]6(C)CCC7[C@](C)(CO)[C@@H](O[C@]8([H])OC[C@H](O)[C@H](O)[C@H]8O)CC[C@]7(C)[C@@]6([H])CC=C5[C@]2([H])C1

InChI

1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1

InChI key

CCRXMHCQWYVXTE-HMRSNRLKSA-N

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SMB00424PHL8327553889
Akebia saponin D ≥98% (HPLC)

Sigma-Aldrich

SML1822

木通皂苷 PK

Platycodin D ≥98% (HPLC)

Sigma-Aldrich

SMB00424

桔梗皂苷D

Asperosaponin VI phyproof® Reference Substance

PHL83275

木通皂苷 PK

Bacoside A3 analytical standard

Supelco

53889

Bacoside A3

form

powder

form

powder

form

-

form

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white to beige

color

-

color

-

color

-

solubility

H2O: 3 mg/mL, clear (warmed)

solubility

-

solubility

-

solubility

-

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

生化/生理作用

木通皂甙 D(ASD)是一种具有生物活性的三萜皂苷,它是从川续断的根茎中分离出来的,用作抗骨质疏松症药物。木通皂甙 D 在多种疾病模型(包括癌症、阿尔茨海默氏病、心血管疾病和骨折)中均显示出治疗效果。木通皂甙 D 可预防 NAFLD 小鼠模型中的非酒精性脂肪肝(NAFLD)肝损伤。ASD 通过自噬调节减少肝脂肪变性和肝细胞凋亡。木通皂甙 D 阻止油酸诱导的脂质小滴积聚并增加自噬通量 BRL 细胞。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of the metabolic syndrome, and the incidence of NAFLD is increasing rapidly. However, appropriate drugs for treatment of NAFLD are lacking. This study aimed to elucidate the protective
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Akebia saponin D (ASD) is a typical bioactive triterpenoid saponin obtained from the rhizome of Dipsacus asper Wall. Previous studies have found that ASD has a hepatoprotective effect in a mouse model. The purpose of this paper was to explore

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