SML1823
Vosaroxin hydrochloride
≥98% (HPLC)
别名:
1,4-Dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid hydrochloride, SNS-595 hydrochloride, Voreloxin hydrochloride
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经验公式（希尔记法）:
C18H19N5O4S · HCl
化学文摘社编号:
分子量:
437.90
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Vosaroxin hydrochloride, ≥98% (HPLC)
InChI
1S/C18H19N5O4S.ClH/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18;/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26);1H/t12-,13-;/m0./s1
SMILES string
O=C(C(C(O)=O)=C1)C2=C(N=C(C=C2)N3C[C@@H]([C@H](C3)NC)OC)N1C4=NC=CS4
InChI key
JJZCCQHWCOXGCL-QNTKWALQSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +42 to +52°, c = 1 in 0.1 M NaOH
color
white to beige
solubility
H2O: 1 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor, causing p53 independent tumor cell apoptosis. Vosaroxin stabilizes cleavage complexes formed by topoisomerase IIα and IIβ, which results in an accumulation of DNA double-strand breaks. Vosaroxin showed antineoplastic activity in multiple solid tumor and hematologic cancer cell lines and has been in clinical trials for AML.
Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Nicholas J Short et al.
Expert review of hematology, 9(6), 529-534 (2016-05-10)
The outcomes of patients with relapsed or refractory acute myeloid leukemia (AML) are dismal, and effective treatment options in this patient population are therefore desperately needed. Vosaroxin is a first-in-class anticancer quinolone derivative that has shown promising activity in patients
Gene C Jamieson et al.
Drugs, 76(13), 1245-1255 (2016-08-04)
Vosaroxin is a first-in-class anticancer quinolone derivative that targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to tumor cell apoptosis. Vosaroxin has chemical and pharmacologic characteristics distinct from other topoisomerase II inhibitors due to its quinolone scaffold.
Christopher B Benton et al.
Future oncology (London, England), 13(2), 125-133 (2016-09-13)
Vosaroxin is a quinolone compound that intercalates DNA and induces TP53-independent apoptosis, demonstrating activity against acute myeloid leukemia (AML) in Phase I-III trials. Here, we examine vosaroxin's mechanism of action and pharmacology, and we review its use in AML to
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