跳转至内容
Merck
CN

SML1845

Thapsigargin

From (Thapsia garganica L seeds), ≥98% (HPLC), calcium ion pumps inhibitor, DMSO solution

别名:

CHEBI:9516, CHEMBL96926, MFCD00083511, UNII-Z96BQ26RZD, Z96BQ26RZD, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C34H50O12
化学文摘社编号:
67526-95-8
分子量:
650.75
UNSPSC Code:
12352200
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

Thapsigargin Ready Made Solution, ≥98% (HPLC), 10 mM in DMSO

SMILES string

O1[C@@H]2[C@]([C@H](C[C@@]([C@H]3[C@@H]([C@H](C(=C32)C)OC(=O)\C(=C/C)\C)OC(=O)CCCCCCC)(OC(=O)C)C)OC(=O)CCC)([C@@](C1=O)(O)C)O

InChI

1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1

InChI key

IXFPJGBNCFXKPI-FSIHEZPISA-N

biological source

(Thapsia garganica L seeds)

assay

≥98% (HPLC)

form

DMSO solution

concentration

10 mM in DMSO

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

相关类别

Application

毒胡萝卜素即配型溶液可作为体内生长和体外翻译检测的阴性对照。

Biochem/physiol Actions

毒胡萝卜素是一种有效的钙离子泵抑制剂，位于骨骼肌、心肌、肌肉和脑组织的肌质网（SR）和内质网（ER）微粒体上。
毒胡萝卜素是一种有效的钙离子泵抑制剂，位于骨骼肌、心肌、肌肉和脑组织的肌质网（SR）和内质网（ER）微粒体上。钙离子泵的抑制会导致细胞内钙离子水平上升。100nM浓度的毒胡萝卜素可有效抑制心肌和骨骼肌中的SR Ca2+ -三磷酸腺苷酶（ATP酶）。毒胡萝卜素还可通过干扰自噬体-溶酶体融合而有效阻断自噬。

Other Notes

在浓度为10 mM的DMSO中提供了毒胡萝卜素即用型溶液。该溶液可用 DMSO 进一步稀释至 2 mM 浓度。建议将预先制好的毒胡萝卜素溶液小等份保存于-20°C下。

存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000478150
0000478150
0000440277
0000440277
0000284597

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice
<BIG>Sari FR, et al.</BIG>
Cellular Physiology and Biochemistry, 167-178 (2010)
M Alsaqati et al.
British journal of pharmacology, 171(3), 701-713 (2013-10-22)
The P2Y₁₄ receptor is the newest member of the P2Y receptor family; it is G(i/o) protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5'-diphosphoglucose) (7-10-fold more potent than UDP-glucose). This study investigated whether P2Y₁₄ receptors were
J Lytton et al.
The Journal of biological chemistry, 266(26), 17067-17071 (1991-09-15)
The role of ATP-dependent calcium uptake into intracellular storage compartments is an essential feature of hormonally induced calcium signaling. Thapsigargin, a non-phorboid tumor promoter, increasingly is being used to manipulate calcium stores because it induces a hormone-like elevation of cytosolic
Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices
<BIG>Harvey J and Collingridge GL</BIG>
Neuroscience Letters, 197-200 (1992)
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest
<BIG>Ganley IG, et al..</BIG>
Molecular Cell, 731-731 (2011)
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持