SML1863
NSC57969
≥98% (HPLC)
别名:
7-(1-Piperidinylmethyl)-8-quinolinol, 7-(Piperidinomethyl)-8-quinolinol, 8-Hydroxy-7-(piperidinomethyl)quinoline
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H18N2O
化学文摘社编号:
分子量:
242.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2
SMILES string
OC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3
InChI key
WXMFPLZGDXLEMN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines
NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
András Füredi et al.
Molecular cancer therapeutics, 16(1), 45-56 (2016-10-21)
Despite significant progress, resistance to chemotherapy is still the main reason why cancer remains a deadly disease. An attractive strategy is to target the collateral sensitivity of otherwise multidrug resistant (MDR) cancer. In this study, our aim was to catalog
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