SML1890
MK204
≥98% (HPLC)
别名:
2-[5-Chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-acetic acid
产品名称
MK204, ≥98% (HPLC)
InChI
1S/C16H9Br5ClNO4/c17-11-8(12(18)14(20)15(21)13(11)19)4-23-16(26)7-2-1-6(22)3-9(7)27-5-10(24)25/h1-3H,4-5H2,(H,23,26)(H,24,25)
InChI key
QYSFXUVFRUYJCZ-UHFFFAOYSA-N
SMILES string
O=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 3 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10).
MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC50 value of 80 nM compared to an IC50 value of 21.7 μM for aldose reductase.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alexandra Cousido-Siah et al.
ACS chemical biology, 11(10), 2693-2705 (2016-10-22)
Human enzyme aldo-keto reductase family member 1B10 (AKR1B10) has evolved as a tumor marker and promising antineoplastic target. It shares high structural similarity with the diabetes target enzyme aldose reductase (AR). Starting from the potent AR inhibitor IDD388, we have
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