SML1907
ESI-05
≥98% (HPLC)
别名:
1,3,5-三甲基-2-[（4-甲基苯基）磺酰基]-苯（ESI-05）, 亚甲基（4-甲基苯基）砜
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选择尺寸
关于此项目
经验公式（希尔记法）:
C16H18O2S
化学文摘社编号:
分子量:
274.38
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
ESI-05, ≥98% (HPLC)
InChI
1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
SMILES string
CC1=CC=C(S(C2=C(C)C=C(C)C=C2C)(=O)=O)C=C1
InChI key
CGPHOZWFSFNOEQ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
Quality Level
相关类别
Application
ESI-05已被用于研究cAMP 2直接激活的蛋白交换对颅脑损伤的作用。
Biochem/physiol Actions
ESI-05是一种靶向cAMP调节的鸟嘌呤核苷酸交换因子（GEF）EPAC2（直接由cAMP 2激活的交换因子）激活的选择性抑制剂，其可靶向两个cAMP结合域的交界面上的EPAC2特异性变构位点。
ESI-05是一种靶向cAMP调节的鸟嘌呤核苷酸交换因子（GEF）EPAC2（直接由cAMP 2激活的交换因子）激活的选择性抑制剂，其可靶向两个cAMP结合域的交界面上的EPAC2特异性变构位点。在无细胞测定中，ESI-05可以高效地以与cAMP竞争的方式抑制cAMP对EAPC2的激活（IC50 = 430 nM；25 μM cAMP），但不可抑制EPAC1或PKA。同时，其可抑制表达EPAC2（而非EPAC1）的HEK293转染子中，cPAC类似物007-AM诱导的细胞Rap1的激活。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Tamara Tsalkova et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(45), 18613-18618 (2012-10-24)
The major physiological effects of cAMP in mammalian cells are transduced by two ubiquitously expressed intracellular cAMP receptors, protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC), as well as cyclic nucleotide-gated ion channels in certain tissues.
Eva Calderón-Sánchez et al.
PloS one, 11(2), e0147375-e0147375 (2016-02-04)
Urocortin-1 (Ucn-1) is an endogenous peptide that protects heart from ischemia and reperfusion (I/R) injuries. Ucn-1 is known to prevent cardiac cell death, but its role in the transcription of specific genes related to survival signaling pathway has not been
Haijun Chen et al.
Journal of medicinal chemistry, 56(3), 952-962 (2013-01-05)
EPAC1 and EPAC2, two isoforms of exchange proteins directly activated by cAMP (EPAC), respond to the second messenger cAMP and regulate a wide variety of intracellular processes under physiological and pathophysiological circumstances. Herein, we report the chemical design, synthesis, and
Ling Zhang et al.
Frontiers in neuroscience, 12, 263-263 (2018-05-10)
Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. TBI-induced neuronal apoptosis is one of the main contributors to the secondary injury process. The aim of this study is to investigate the involvement of Exchange protein
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