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SML1908

Syrosingopine

Name: Syrosingopine
Brand: SIGMA
Price: 639.51 CNY
Availability: InStock

别名:

(3β,16β,17α,18β,20α)-18-[[4-[(Ethoxycarbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-yohimban-16-carboxylic acid methyl ester, Methyl reserpate ester of syringic acid ethyl carbonate

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25 G

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25 G

¥639.51

100 G

¥1,653.99

500 G

¥2,455.37

About This Item

经验公式（希尔记法）:

C₃₅H₄₂N₂O₁₁

CAS Number:

84-36-6

分子量:

666.71

UNSPSC代码:

12352200

NACRES:

NA.77

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Sigma-Aldrich

Z366218

Cryo-Babies^® 标签

Z740246

Direct Thermal Cryo-Tags^®

Z743335

Cryo-Babies^® 标签

Z743334

Cryo-Babies^® 标签

Z743338

Cryo-Babies^® 标签

Z743339

激光低温标签^®

Sigma-Aldrich

Z378992

激光低温标签^®

Sigma-Aldrich

Z376914

Cryo-Tags^® 标签

HS120879

Slide staining tray with lid

Z743333

Cryo-Babies^® 标签

表单

powder

质量水平

100

颜色

white to light brown

溶解性

DMSO: 10 mg/mL, clear

SMILES字符串

O=C(OC)[C@@H]1[C@]2([H])C[C@@]3([H])C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@]2([H])C[C@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H]1OC

InChI

1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)34(39)45-6/h8-9,12-13,15,19,23,25,28-29,32,36H,7,10-11,14,16-17H2,1-6H3/t19-,23+,25-,28-,29+,32+/m1/s1

InChI key

ZCDNRPPFBQDQHR-SSYATKPKSA-N

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此商品	423238	H8384	H9262
09963 羟丙基甲基纤维素	423238 羟丙基甲基纤维素	H8384 羟丙基甲基纤维素	H9262 羟丙基甲基纤维素
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
solubility water: 100 mg/10 mL, clear, colorless	solubility -	solubility water: 10 mg/mL, clear to slightly hazy	solubility -
form powder	form powder	form powder	form powder
storage temp. room temp	storage temp. -	storage temp. room temp	storage temp. -
color faint beige	color -	color beige	color beige
composition hydroxylpropoxyl content, ~9%	composition -	composition -	composition -

应用

Syrosingopine has been used as a monocarboxylate transporter (MCT) inhibitor

to study its effects on anti-CD147-induced metabolon disruption in human breast cancer cells[1]
to study its effects on Cryptosporidium parvum-infected HCT-8 cells[2]
in orthogonal linear separation analysis (OLSA)-derived decomposed analysis[3]

生化/生理作用

Syrosingopine is a derivative of reserpine[3] and inhibits monocarboxylate lactate transporters 1 and 4 (MCT1/4).[2]

Syrosingopine is an antihypertensive agent related to reserpine that was found to potentiate the anticancer effects of the antidiabetic agent metformin and phenformin without harmful effects on normal cells. Syrosingopine was also found to potentiate the anticancer activity of mitochondrial electron transport chain (ETC) inhibitors. Its mechanism of action is currently unknown but may involve inhibition of glycolytic enzyme α-enolase rather than its known activity as an inhibitor of vesicular monoamine transporters VMAT1 and VMAT2.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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