Merck
CN

SML1924

Sigma-Aldrich

T1AM

≥98% (HPLC)

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别名:
3-碘胸腺嘧啶 盐酸盐, 4-[4-(2-氨基乙基)-2-?碘苯氧基]苯酚盐酸盐(1:1)
Empirical Formula (Hill Notation):
C14H14INO2 · HCl
分子量:
391.63
MDL编号:

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

H2O: 10 mg/mL, clear

储存温度

2-8°C

SMILES string

OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1.[H]Cl

InChI

1S/C14H14INO2.ClH/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12;/h1-6,9,17H,7-8,16H2;1H

InChI key

RVKVVMXTPQCCIX-UHFFFAOYSA-N

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此商品
T2879SML0794W1895
T1AM ≥98% (HPLC)

Sigma-Aldrich

SML1924

T1AM

Tyramine hydrochloride ≥98%

Sigma-Aldrich

T2879

酪胶 盐酸盐

Sigma-Aldrich

Sigma-Aldrich

SML0794

T2AA hydrochloride

WAY-100135 ≥98% (HPLC)

Sigma-Aldrich

W1895

WAY-100135

form

powder

form

-

form

powder

form

powder

color

white to beige

color

-

color

white to beige

color

white to off-white

solubility

H2O: 10 mg/mL, clear

solubility

H2O: soluble 50 mg/ml, clear, colorless to faintly yellow

solubility

DMSO: 10 mg/mL, clear

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

生化/生理作用

3-3-碘类甲腺质(T1AM)存在于脊椎动物组织和循环系统中。其生理作用与甲状腺激素相反。T1AM既是一种神经调节剂,也是一种激素样分子。
T1AM(3-3-碘类甲腺质)是一种源自甲状腺激素的内源性生物胺。 T1AM是痕量胺相关受体TAAR1 (TAR1, Ta1)的强效激动剂,而 TAAR1 是一种主要在大脑中发现的 GPCR。

象形图

Exclamation markEnvironment

警示用语:

Warning

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3


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Thyroid : official journal of the American Thyroid Association, 26(12), 1656-1673 (2016-09-22)
Thyronamines (3-T
Alexandra G Ianculescu et al.
Molecular bioSystems, 6(8), 1338-1344 (2010-07-14)
3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with distinct biological effects that are largely opposite those of thyroid hormone. Administration of T(1)AM to rodents results in rapid and profound reduction in body temperature, heart rate, and metabolism. The structural
Annunziatina Laurino et al.
European journal of pharmacology, 793, 35-42 (2016-11-07)
3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled monoaminergic receptors, including trace amine associated receptors, suggesting the amine may exert a modulatory role on the monoaminergic
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Human trace amines (TAs) are endogenous compounds, previously almost ignored in human pathology for many reasons (difficulty of their measurement in biological fluids, unknown receptors for elusive amines), are now considered to play a significant role in synaptic transmission within

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