SML1941
CGP3466B 马来酸盐
≥98% (HPLC)
别名:
CGP 3466B, N-（二苯并[[b，f]氧杂环庚烷-10-基甲基）-N-甲基-N-（2-丙炔基）胺单马来酸盐, Omigapil 马来酸盐, TCH346, 二苯并[b，f] 氧杂环庚烷-10-甲胺，N-甲基-N-2-丙炔-1-基，（2Z）-2-丁烯二酸酯（1：1）
SMILES string
N(CC1=Cc2c(cccc2)Oc3c1cccc3)(CC#C)C.OC(=O)\C=C/C(=O)O
InChI
1S/C19H17NO.C4H4O4/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19;5-3(6)1-2-4(7)8/h1,4-11,13H,12,14H2,2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
SQAZQLMBEHYFJA-BTJKTKAUSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
3-磷酸甘油醛脱氢酶（GAPDH）的抑制剂，具有神经保护作用。
CGP3466B，也称为Omigapil马来酸酯和TCH346，是3-磷酸甘油醛脱氢酶（GAPDH）的一种有效抑制剂。它已显示出具有神经保护活性，并于2016年5月获得了美国FDA快速审核资格，以用于先天性肌营养不良的治疗。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Prasun Guha et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1417-1422 (2016-01-21)
Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the cytotoxic actions of cocaine reflect selective enhancement of
Natasha T Snider et al.
PloS one, 11(8), e0160982-e0160982 (2016-08-12)
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) signals during cellular stress via several post-translational modifications that change its folding properties, protein-protein interactions and sub-cellular localization. We examined GAPDH properties in acute mouse liver injury due to ethanol and/or acetaminophen (APAP) treatment.
Qing Yu et al.
PloS one, 8(6), e65468-e65468 (2013-06-14)
Congenital muscular dystrophy is a distinct group of diseases presenting with weakness in infancy or childhood and no current therapy. One form, MDC1A, is the result of laminin alpha-2 deficiency and results in significant weakness, respiratory insufficiency and early death.
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