SML1946
AM-9074
≥98% (HPLC)
别名:
(R)-1-(4-((5-Methoxypyridin-3-yl)oxy)-5-(tetrahydro-2H-pyran-3-yl)pyridin-2-yl)-3-methylurea, Urea, N-[4-[(5-methoxy-3-pyridinyl)oxy]-5-[(3R)-tetrahydro-2H-pyran-3-yl]-2-pyridinyl]-N′-methyl-
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Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CNC(NC1=CC(OC2=CC(OC)=CN=C2)=C([C@H]3CCCOC3)C=N1)=O
InChI
1S/C18H22N4O4/c1-19-18(23)22-17-7-16(26-14-6-13(24-2)8-20-9-14)15(10-21-17)12-4-3-5-25-11-12/h6-10,12H,3-5,11H2,1-2H3,(H2,19,21,22,23)/t12-/m0/s1
InChI key
APSOPISMEDAYTH-LBPRGKRZSA-N
Biochem/physiol Actions
AM-9074 is a potent activator of glucokinase, which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-9074 had an EC50 value of 160 nM with good solubility, oral bioavailability and acceptable clearance in rodents, and was shown to lower plasma glucose levels.
Glucokinase activator
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable