DIM-C-pPhCO2Me

Name: DIM-C-pPhCO2Me
Brand: SIGMA

≥98% (HPLC)

别名:

4-(di-1H-Indol-3-ylmethyl)-benzoic acid methyl ester, Benzoic acid, 4-(di-1H-indol-3-ylmethyl)-, methyl ester

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₅H₂₀N₂O₂

CAS Number:

151358-48-4

分子量:

380.44

UNSPSC代码:

12352200

NACRES:

NA.77

方案

≥98% (HPLC)

表单

powder

颜色

pink to light red

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(OC)C1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=CC=CC=C54)C=C1

InChI

1S/C25H20N2O2/c1-29-25(28)17-12-10-16(11-13-17)24(20-14-26-22-8-4-2-6-18(20)22)21-15-27-23-9-5-3-7-19(21)23/h2-15,24,26-27H,1H3

InChI key

BBAOKSZCULLDIW-UHFFFAOYSA-N

生化/生理作用

DIM-C-pPhCO2Me is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhCO2Me decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231 breast cancer cells. DIM-C-pPhCO2Me inhibits migration of Rh30 and MDA-MB-231 cancer cells.

DIM-C-pPhCO₂Me is also known as 1,1-bis(3′-indolyl)-1-(p-carboxymethylphenyl)methane. In pancreatic and colon cancer cells, DIM-C-pPhCO₂Me plays an inhibitory role on cell migration. DIM-C-pPhCO₂Me prevents the action of mechanistic target of rapamycin (mTOR) and reduces the multiplication and survival of cancer cells. It stimulates reactive oxygen species (ROS) in various cancer cell lines.

NR4A1 (Nur77) antagonist that exhibit potent anticancer activity