SML1998
KLH45
≥98% (HPLC)
别名:
N-Cyclohexyl-N-phenethyl-4-(4-(trifluoromethoxy)phenyl)-2H-1,2,3-triazole-2-carboxamide
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关于此项目
经验公式（希尔记法）:
C24H25F3N4O2
化学文摘社编号:
分子量:
458.48
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
oil
InChI
1S/C24H25F3N4O2/c25-24(26,27)33-21-13-11-19(12-14-21)22-17-28-31(29-22)23(32)30(20-9-5-2-6-10-20)16-15-18-7-3-1-4-8-18/h1,3-4,7-8,11-14,17,20H,2,5-6,9-10,15-16H2
InChI key
FYOYNRLSBYWAHL-UHFFFAOYSA-N
SMILES string
O=C(N(CCC1=CC=CC=C1)C2CCCCC2)N(N=C3)N=C3C4=CC=C(OC(F)(F)F)C=C4
assay
≥98% (HPLC)
form
oil
color
colorless to light yellow
storage temp.
2-8°C
Biochem/physiol Actions
In vivo-active, potent and selective irreversible inhibitor of DDHD2
KLH45 is an in vivo-active, potent and selective irreversible inhibitor of DDHD2. KLH45 inactivates brain levels of DDHD2 and increases levels of triglycerides in mouse brain.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jordon M Inloes et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(41), 14924-14929 (2014-10-01)
Complex hereditary spastic paraplegia (HSP) is a genetic disorder that causes lower limb spasticity and weakness and intellectual disability. Deleterious mutations in the poorly characterized serine hydrolase DDHD2 are a causative basis for recessive complex HSP. DDHD2 exhibits phospholipase activity
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