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Merck
CN

SML2008

噻托溴铵 一水合物

≥98% (HPLC), NF-κB activation inhibitor, powder

别名:

(1α, 2β, 4 β, 5α, 7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide monohydrate, 3-Oxa-9-azoniatricyclo[3.3.1.02,4]?nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, hydrate (1:1:1), (1α,2β,4β,5α,7β), 6β,7β-epoxy-3β-hydroxy-8-methyl-1αH,5αH-tropanium bromide monohydrate, di-2-thienylglycolate

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关于此项目

经验公式（希尔记法）:
C19H22BrNO4S2 · H2O
化学文摘社编号:
411207-31-3
分子量:
490.43
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD23704176

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产品名称

噻托溴铵 一水合物, ≥98% (HPLC)

InChI

1S/C19H22NO4S2.BrH.H2O/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H;1H2/q+1;;/p-1/t11?,12-,13+,16?,17?;;

SMILES string

[H]O[H].O=C(C(C1=C([H])C([H])=C([H])S1)(O[H])C2=C([H])C([H])=C([H])S2)O[C@@]3([H])C([H])([H])[C@@]4([H])[C@@]5([H])[C@@](O5)([H])[C@](C3([H])[H])([H])[N+]4(C([H])([H])[H])C([H])([H])[H].[Br-]

InChI key

MQLXPRBEAHBZTK-YQMLGFMRSA-M

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

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相关类别

Application

Tiotropium bromide monohydrate may be used as a long-acting muscarinic receptor antagonist (LAMA) in a comparative study to explore its efficacy in the downregulation of the cough reflex in rabbits.

Biochem/physiol Actions

Tiotropium Bromide is an anticholinergic bronchodilator. It is considered a long-acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for chronic obstructive pulmonary disease (COPD) and asthma.
Tiotropium bromide exhibits more beneficial effects on pulmonary function than other anticholinergic and β-2 adrenergic agents. Tiotropium can prevent the proliferation of fibroblasts and myofibroblasts induced by acetylcholine. It can block human monocyte chemotaxis.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000202010
0000154224
0000154224
0000202010
0000136163

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Masaki Ogoda et al.
Journal of pharmacological sciences, 115(3), 374-382 (2011-03-02)
The aim of the current study was to characterize comparatively the binding of muscarinic receptor in the lung of rats intratracheally administered anticholinergic agents (tiotropium, ipratropium, glycopyrrolate) used clinically to treat chronic obstructive pulmonary disease (COPD) and asthma. Binding parameters
Tiotropium Bromide Inhibits Human Monocyte Chemotaxis
Kurai M, et al.
3D Bioprinting for Reconstructive Surgery, 5, 86-86 (2012)
Timothy E Albertson et al.
Expert opinion on investigational drugs, 26(1), 35-49 (2016-12-09)
Parasympathetic neurons utilize the neurotransmitter acetylcholine to modulate and constrict airway smooth muscles at the muscarinic acetylcholine receptor. Inhaled agents that antagonize the muscarinic (M) acetylcholine receptor, particularly airway M3 receptors, have increasing data supporting use in persistent asthma. Areas
Donatella Mutolo et al.
Pulmonary pharmacology & therapeutics, 38, 1-9 (2016-04-16)
Long-acting muscarinic receptor antagonists (LAMAs) have been reported to attenuate cough in preclinical and clinical studies. The present study was performed on rabbits to compare aclidinium and tiotropium efficacy in the downregulation of the cough reflex. This reflex was evoked
Neil C Thomson
Expert opinion on pharmacotherapy, 18(3), 283-293 (2017-01-19)
Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta

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