SML2019
DS44170716
≥98% (HPLC)
别名:
(3aR,4S,9bS)-rel-8-bromo-3a,4,5,9b-tetrahydro-4-(4-methylphenyl)-3H-cyclopenta[c]quinoline-6-carboxylic acid, 8-Bromo-3a,4,5,9b-tetrahydro-4-(4-methylphenyl)-3H-cyclopenta[c]quinoline-6-carboxylic acid
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
2-8°C
相关类别
生化/生理作用
DS44170716 is an inhibitor of Ca2+-induced mitochondrial permeability transition. It has a different mechanism of action from cyclosporin A that is not dependent on PPIF, a peptidyl-prolyl cis-trans isomerase associated with the mitochondrial permeability transition pore (MPTP). Instead DS44170716 blocks Ca2+ flux into the mitochondria by decreasing mitochondrial membrane potential and inhibits enzyme activities of mitochondrial respiratory chain complex III, IV and V. It showed a similar potent protective effect against Ca2+-induced death in human liver cells as Cyclosporin A.
Inhibitor of Ca2+-induced mitochondrial permeability transition
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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