SML2027
L-2-oxothiazolidine-4-carboxylic acid propargyl amide
≥98% (HPLC)
别名:
(R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide, OTC propargyl amide, OTC-PA
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关于此项目
经验公式（希尔记法）:
C7H8N2O2S
化学文摘社编号:
分子量:
184.22
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
InChI
1S/C7H8N2O2S/c1-2-3-8-6(10)5-4-12-7(11)9-5/h1,5H,3-4H2,(H,8,10)(H,9,11)/t5-/m0/s1
InChI key
MWEQVHWJNCRXGP-YFKPBYRVSA-N
SMILES string
C#CCNC([C@@H]1CSC(N1)=O)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
L-2-oxothiazolidine-4-carboxylic acid propargyl amide is a cell penetrant, potent and selective competitive inhibitor of cystathionine-γ-lyase that completely abrogated L-cysteine-induced vasorelaxation in tissue.
cell penetrant, potent and selective competitive inhibitor of cystathionine-γ-lyase
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Angela Corvino et al.
Scientific reports, 6, 34398-34398 (2016-10-07)
Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis. It is endogenously synthesized mainly by two pyridoxal-5'-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ß-synthase (CBS) and cystathionine-γ-lyase (CSE). Research
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