SML2032
Win6mer trifluoroacetate salt
≥98% (HPLC)
别名:
Ac-ARTEVY-NH2 trifluouroaceate salt
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关于此项目
经验公式（希尔记法）:
C34H54N10O11 · xC2HF3O2
化学文摘社编号:
分子量:
778.85 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
InChI
1S/C34H54N10O11/c1-16(2)26(32(54)42-24(28(35)50)15-20-8-10-21(47)11-9-20)43-31(53)23(12-13-25(48)49)41-33(55)27(18(4)45)44-30(52)22(7-6-14-38-34(36)37)40-29(51)17(3)39-19(5)46/h8-11,16-18,22-24,26-27,45,47H,6-7,12-15H2,1-5H3,(H2,35,50)(H,39,46)(H,40,51)(H
InChI key
DYNVFAUYAHJESK-NGPBCSSISA-N
SMILES string
C[C@H](NC(C)=O)C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=C(C=C1)O)=O)C(C)C)=O)CCC(O)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O
assay
≥98% (HPLC)
form
film (Clear)
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
Win6mer is a potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes that does not inhibit MLL2-4 or SETd1B complexes. Win6mer potently binds to WDR5 in a 310-helical conformation. It does not inhibit isolated SET domain activity.
potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Nilda L Alicea-Velázquez et al.
The Journal of biological chemistry, 291(43), 22357-22372 (2016-08-27)
MLL1 belongs to the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, composed of MLL1-4 and SETd1A/B. MLL1 translocations are present in acute leukemias, and mutations in several family members are associated with cancer and developmental disorders. MLL1 associates
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