SML2042
27-羟基胆固醇
≥98% (HPLC), LXR agonist, powder
别名:
25（R）-27-羟基胆固醇, 27-OHC, （25R）-26-羟基胆固醇, （25R）-胆甾-5-烯-3b，26-二醇
Product Name
27-羟基胆固醇, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D -25 to -35°, c = 0.5 in chloroform-d
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCC[C@H](CO)C)C)(CC3)C)CC=C2C1)C
InChI
1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
FYHRJWMENCALJY-YSQMORBQSA-N
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相关类别
一般描述
27-羟基胆固醇可诱导谷胱甘肽耗竭、细胞凋亡、活性氧（ROS）产生和炎症。
生化/生理作用
27-羟基胆固醇是一种外围衍生的氧固醇，由CYP27A1酶产生。人们对氧固醇，尤其是大脑中的氧固醇越来越感兴趣。脑胆固醇代谢受损与几种神经退行性疾病有关。27-羟基胆固醇可穿过血脑屏障并与阿尔茨海默病有关。它在体外可作为LXRα和LXRβ的激活剂，EC50值分别为85和71 nM，其也是是胆固醇合成的抑制剂。 27-羟基胆固醇还被证明可与雌激素受体-α (ERα)和Erβ结合，充当内源性选择性雌激素受体调节剂(SERM)。在乳腺癌的鼠模型中，27-羟基胆固醇可显著增加肿瘤的生长和转移。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Neurochemical Aspects of Alzheimer's Disease: Risk Factors, Pathogenesis, Biomarkers, and Potential Treatment Strategies (2017)
Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease
D Risso et al.
Food & function, 12(2), 771-780 (2021-01-05)
Oxysterols are products of enzymatic and/or chemical cholesterol oxidation. While some of the former possess broad antiviral activities, the latter mostly originate from the deterioration of the nutritional value of foodstuff after exposure to heat, light, radiation and oxygen, raising
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