SML2053
Lalistat 2
≥98% (HPLC), lysosomal acid lipase (LAL) inhibitor, powder
别名:
1-Piperidinecarboxylic acid 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester, Lalistat-2
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关于此项目
经验公式（希尔记法）:
C13H20N4O2S
化学文摘社编号:
分子量:
296.39
UNSPSC Code:
41106300
NACRES:
NA.77
MDL number:
产品名称
Lalistat 2, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3
InChI key
PNYYVHOTXOEBEV-UHFFFAOYSA-N
Application
Lalistat 2 has been used as a lysosomal acid lipase (LAL) inhibitor to study its effects on hypoxia-inducible factor (HIF) in mice. It has also been used as a LAL inhibitor to study LAL activity on dried blood spot cards.
Biochem/physiol Actions
Lalistat-2 is a potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa). Lalistat-2 affects lipid droplets morphology and localization.
potent and specific competitive inhibitor of the lysosomal acid lipase (LAL/Lipa).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Chiara Pavanello et al.
Pharmacological research, 147, 104362-104362 (2019-07-23)
Lysosomal acid lipase (LAL) is responsible for the hydrolysis of cholesteryl esters (CE) and triglycerides (TG) within the lysosomes; generated cholesterol and free fatty acids (FFA) are released in the cytosol where they can regulate their own synthesis and metabolism.
Maidina Tuohetahuntila et al.
The Journal of biological chemistry, 292(30), 12436-12448 (2017-06-16)
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and retinyl esters (REs). We previously provided evidence for the presence
Stefanie Schlager et al.
Oncotarget, 8(25), 40037-40051 (2017-04-14)
Degradation of lysosomal lipids requires lysosomal acid lipase (LAL), the only intracellular lipase known to be active at acidic pH. We found LAL to be expressed in murine immune cells with highest mRNA expression in macrophages and neutrophils. Furthermore, we
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML2053-5MG | 04061833054024 |
| SML2053-25MG | 04061833054017 |