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SML2054

SEA0400

Name: SEA0400
Brand: SIGMA

≥98% (HPLC), Na+−Ca++ exchanger (NCX) inhibitor, powder

别名:

2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺, 2- [4-[（2,5-二氟苯基）甲氧基]苯氧基] -5-乙氧苯胺

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关于此项目

经验公式（希尔记法）:

C₂₁H₁₉F₂NO₃

化学文摘社编号:

223104-29-8

分子量:

371.38

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD07772188

Assay:

≥98% (HPLC)

Form:

powder

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产品名称

SEA0400, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

shipped in

ambient

storage temp.

−20°C

SMILES string

CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(F)=C3)C=C2)C(N)=C1

InChI

1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3

InChI key

YSUBLPUJDOWYDP-UHFFFAOYSA-N

Biochem/physiol Actions

Na+−Ca++ 交换蛋白（NCX）的有效选择性抑制剂。

SEA0400是Na⁺/Ca²⁺交换蛋白（NCX）的有效选择性抑制剂。SEA0400可有效抑制大鼠星形胶质细胞、小胶质细胞、培养神经元和心肌细胞中Na⁺/Ca²⁺交换蛋白的活性。

wgk

WGK 3

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000495248

0000472940

0000469946

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SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.

T Matsuda et al.

The Journal of pharmacology and experimental therapeutics, 298(1), 249-256 (2001-06-16)

The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) on the Na+-Ca2+ exchanger (NCX) was investigated and compared against that of 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943). In addition, the effects of SEA0400 on reperfusion injury in vitro and in vivo were examined. SEA0400

Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation.

Torsten Christ et al.

European journal of pharmacology, 788, 286-293 (2016-07-05)

The Na(+)/Ca(2+) exchanger (NCX) plays a major role in myocardial Ca(2+) homoeostasis, but is also considered to contribute to the electrical instability and contractile dysfunction in chronic atrial fibrillation (AF). Here we have investigated the effects of the selective NCX

Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes.

Kanna Yamashita et al.

Naunyn-Schmiedeberg's archives of pharmacology, 389(11), 1205-1214 (2016-08-03)

Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and selective Na+/Ca2+ exchange (NCX) inhibitor by using various cells transfected with NCX using the 45Ca2+ fluorescent technique. However, the electrophysiological study of YM-244769 on NCX had not been

全球贸易项目编号

货号	GTIN
SML2054-5MG	04061832568607
SML2054-25MG	04061832568591

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