SML2054
SEA0400
≥98% (HPLC), Na+−Ca++ exchanger (NCX) inhibitor, powder
别名:
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺, 2- [4-[（2,5-二氟苯基）甲氧基]苯氧基] -5-乙氧苯胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C21H19F2NO3
化学文摘社编号:
分子量:
371.38
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
SEA0400, ≥98% (HPLC)
InChI
1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3
SMILES string
CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(F)=C3)C=C2)C(N)=C1
InChI key
YSUBLPUJDOWYDP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
shipped in
ambient
storage temp.
−20°C
Biochem/physiol Actions
Na+−Ca++ 交换蛋白（NCX）的有效选择性抑制剂。
SEA0400是Na+/Ca2+交换蛋白（NCX）的有效选择性抑制剂。SEA0400可有效抑制大鼠星形胶质细胞、小胶质细胞、培养神经元和心肌细胞中Na+/Ca2+交换蛋白的活性。
wgk
WGK 3
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Torsten Christ et al.
European journal of pharmacology, 788, 286-293 (2016-07-05)
The Na(+)/Ca(2+) exchanger (NCX) plays a major role in myocardial Ca(2+) homoeostasis, but is also considered to contribute to the electrical instability and contractile dysfunction in chronic atrial fibrillation (AF). Here we have investigated the effects of the selective NCX
T Matsuda et al.
The Journal of pharmacology and experimental therapeutics, 298(1), 249-256 (2001-06-16)
The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) on the Na+-Ca2+ exchanger (NCX) was investigated and compared against that of 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943). In addition, the effects of SEA0400 on reperfusion injury in vitro and in vivo were examined. SEA0400
Kanna Yamashita et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(11), 1205-1214 (2016-08-03)
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and selective Na+/Ca2+ exchange (NCX) inhibitor by using various cells transfected with NCX using the 45Ca2+ fluorescent technique. However, the electrophysiological study of YM-244769 on NCX had not been
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