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安全信息

SML2082

Sigma-Aldrich

Scrambled 10Panx1 trifluoroacetate salt

≥98% (HPLC)

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别名:
10PanxSCR TFA, FSVYWAQADR TFA, L-phenylalanyl-L-seryl-L-valyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-alanyl-L-a-aspartyl-L-arginine TFA, Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg TFA, SCPanx, TFA, Scrambled 10Panx TFA
经验公式（希尔记法）:
C58H79N15O16 · xC2HF3O2
CAS号:
1315378-72-3
分子量:
1242.34 (free base basis)
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

film (Colorless)

颜色

white to off-white

运输

wet ice

储存温度

−20°C

InChI

1S/C58H79N15O16/c1-29(2)47(73-55(86)44(28-74)72-50(81)37(59)23-32-11-6-5-7-12-32)56(87)71-41(24-33-16-18-35(75)19-17-33)53(84)70-42(25-34-27-64-38-14-9-8-13-36(34)38)52(83)66-30(3)48(79)67-39(20-21-45(60)76)51(82)65-31(4)49(80)69-43(26-46(77)78)54(85)68-40(57(88)89)15-10-22-63-58(61)62/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,82)(H,66,83)(H,67,79)(H,68,85)(H,69,80)(H,70,84)(H,71,87)(H,72,81)(H,73,86)(H,77,78)(H,88,89)(H4,61,62,63)

InChI key

VNQGVHMGXBRHRA-UHFFFAOYSA-N

生化/生理作用

SCPanx (10PanxSCR) corresponds to the scrambled version of the pannexin-1 (panx1) inhibitor peptide 10panx1 and serves as a negative control peptide in pannexin-1 inhibitory studies involving 10panx1 treatment both in vitro and in vivo.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Paul W Furlow et al.
Nature cell biology, 17(7), 943-952 (2015-06-23)
During metastatic progression, circulating cancer cells become lodged within the microvasculature of end organs, where most die from mechanical deformation. Although this phenomenon was first described over a half-century ago, the mechanisms enabling certain cells to survive this metastasis-suppressive barrier
Philipp Prager et al.
PloS one, 11(10), e0165653-e0165653 (2016-10-28)
Systemic hypertension is a risk factor of age-related macular degeneration (AMD), a chronic inflammatory disease. Acute hypertension is caused by increased extracellular osmolarity after intake of dietary salt (NaCl). We determined in cultured human retinal pigment epithelial (RPE) cells whether
Juan Mauricio Garré et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(17), 4785-4801 (2016-04-29)
We show here that the growth factor FGF-1 is proinflammatory in the spinal cord and explore the inflammatory mechanisms. FGF-1 applied to rat spinal astrocytes in culture initiates calcium signaling and induces secretion of ATP that within minutes increases membrane
Stephani Velasquez et al.
Journal of immunology (Baltimore, Md. : 1950), 196(10), 4338-4347 (2016-04-15)
Pannexin1 (Panx1) channels are large high conductance channels found in all vertebrates that can be activated under several physiological and pathological conditions. Our published data indicate that HIV infection results in the extended opening of Panx1 channels (5-60 min), allowing
Nicholas L Weilinger et al.
Nature neuroscience, 19(3), 432-442 (2016-02-09)
Overactivation of neuronal N-methyl-D-aspartate receptors (NMDARs) causes excitotoxicity and is necessary for neuronal death. In the classical view, these ligand-gated Ca(2+)-permeable ionotropic receptors require co-agonists and membrane depolarization for activation. We report that NMDARs signal during ligand binding without activation
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