SML2083
[Ala13]-Apelin-13 三氟乙酸盐
≥96% (HPLC)
别名:
(F13A)apelin-13, Apelin-13(F13A), Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala TFA, L-谷氨酰胺基-L-精氨酸基-L-脯氨酰基-L-精氨酸基-L-亮氨酰-L-丝氨酰-L-组氨酸基-L-赖氨酰糖基-L-脯氨酰基-L-甲硫酰基-L-脯氨酰基-L-丙氨酸TFA, QRPRLSHKGPMPA TFA, [Ala-13] apelin-13, 丙氨酸apelin-13
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关于此项目
经验公式（希尔记法）:
C63H107N23O16S · xC2HF3O2
化学文摘社编号:
分子量:
1474.73 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
产品名称
[Ala13]-Apelin-13 三氟乙酸盐, ≥96% (HPLC)
assay
≥96% (HPLC)
form
powder
color
white to beige
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
在C末端（F13A）具有Phe-Ala取代的Apelin-13，并作为针对apelin依赖性APJ功能的拮抗剂。
（Ala13）-Apelin-13对应于在C末端（F13A）具有Phe-Ala取代的Apelin-13，并可在培养和体内动物研究中均作为针对apelin依赖性APJ功能的拮抗剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
İlknur Birsen et al.
The journal of physiological sciences : JPS, 67(3), 373-385 (2016-07-03)
The objective of this study was to explore the role of apelin in the healing of gastric lesions induced by stress. Male Wistar rats were exposed to water immersion and restraint stress (WIRS) for 6 h with or without the apelin
Dennis K Lee et al.
Endocrinology, 146(1), 231-236 (2004-10-16)
The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The distribution of the apelin peptides and receptor are widespread in the central nervous system and periphery, with reported roles in the hypothalamic-pituitary-adrenal axis, blood pressure regulation
Xue Han et al.
Atherosclerosis, 244, 1-8 (2015-11-19)
Vascular calcification (VC) is closely related to cardiovascular events in chronic kidney disease (CKD). Apelin has emerged as a potent regulator of cardiovascular function, but its role in VC during CKD remains unknown. We determined whether apelin plays a role
Frédéric Adam et al.
Blood, 127(7), 908-920 (2015-12-05)
Apelin peptide and its receptor APJ are directly implicated in various physiological processes ranging from cardiovascular homeostasis to immune signaling. Here, we show that apelin is a key player in hemostasis with an ability to inhibit thrombin- and collagen-mediated platelet
Anne Drougard et al.
Antioxidants & redox signaling, 20(4), 557-573 (2013-07-25)
We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. An intracerebroventricular (icv) injection of a high dose of apelin
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