CN
所有图片(1)
别名:
1- [4-（二氟甲氧基）-3-[（四氢-3-呋喃基）氧基]苯基] -3-甲基-1-丁酮, FFPM, ZL-n-91
经验公式（希尔记法）:
C16H20F2O4
CAS号:
分子量:
314.32
检测方案
≥98% (HPLC)
形式
oil
颜色
colorless to light brown
储存温度
2-8°C
SMILES string
O=C(CC(C)C)C1=CC=C(OC(F)F)C(OC2CCOC2)=C1
生化/生理作用
Roflupram（FFPM）是有效的抗炎性磷酸二酯酶4（PDE4）抑制剂，可通过增强自噬抑制小胶质细胞炎性体活化。在小胶质细胞BV-2中，roflupram提高了微管相关蛋白1轻链3 Ⅱ（LC3-II）的水平，降低了自噬受体泛素结合蛋白p62（SQSTM1），从而增强自噬、降低炎性体的活化、抑制IL-1β的产生。 发现roflupram（FFPM）可以逆转APP/PS1转基因小鼠的学习和记忆缺陷。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
分析证书(COA)
输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。
已有该产品？
为方便起见，与您过往购买产品相关的文件已保存在文档库中。
难以找到您所需的产品或批次号码？
如何查找产品货号
在网站页面上，产品编号会附带包装尺寸/数量一起显示（例如：T1503-25G）。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).
示例
T1503
货号
-
25G
包装规格/数量
其它示例：
705578-5MG-PW
PL860-CGA/SHF-1EA
MMYOMAG-74K-13
1000309185
输入内容 1.000309185)
遇到问题？欢迎随时联系我们技术服务 寻求帮助
如何查找COA批号
批号可以在产品标签上"批“ （Lot或Batch）字后面找到。
Aldrich 产品
如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。
如果您查询到的批号含有填充代码（例如 STBB0728K9），请输入去除填充代码K9的批号：STBB0728。
未找到您寻找的产品？
部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。
Haibiao Guo et al.
Neuropharmacology, 116, 260-269 (2017-01-10)
Thus far, phosphodiesterase-4 (PDE4) inhibitors have not been approved for application in Alzheimer's disease (AD) in a clinical setting due to severe side effects, such as nausea and vomiting. In this study, we investigated the effect of FFPM, a novel
Shilong Zheng et al.
Journal of medicinal chemistry, 51(24), 7673-7688 (2008-12-04)
Phosphodiesterase 4 catalyzes the hydrolysis of cyclic AMP and is a target for the development of anti-inflammatory agents. We have designed and synthesized a series of phenyl alkyl ketones as PDE4 inhibitors. Among them, 13 compounds were identified as having
Hui-Fang Tang et al.
International immunopharmacology, 10(4), 406-411 (2010-01-16)
In the present study, we investigated the effect of classic PDE4 inhibitor rolipram and novel PDE4 inhibitor ZL-n-91 on LPS-induced acute lung injury (ALI) in mice and its mechanism. ALI was induced in ICR mice by instilling intratracheally with LPS
Tingting You et al.
ACS chemical neuroscience, 8(11), 2381-2392 (2017-06-13)
Inhibition of phosphodiesterase 4 (PDE4) suppressed the inflammatory responses in the brain. However, the underlying mechanisms are poorly understood. Roflupram (ROF) is a novel PDE4 inhibitor. In the present study, we found that ROF enhanced the level of microtubule-associated protein
Dan Li et al.
International immunopharmacology, 90, 107176-107176 (2020-11-28)
Roflupram (ROF) is a novel phosphodiesterase 4 inhibitor. We previously found that ROF suppressed the production of pro-inflammatory factors in microglial cells; however, the underlying mechanisms are largely unknown. The present study aimed to elucidate the underlying molecular mechanisms of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门