SML2109
ST034307
≥98% (HPLC)
别名:
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one, 6-Chloro-2-(trichloromethyl)chromen-4-one
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关于此项目
经验公式（希尔记法）:
C10H4Cl4O2
化学文摘社编号:
分子量:
297.95
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H
InChI key
NTDHYMSVCBGQJF-UHFFFAOYSA-N
SMILES string
ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O
assay
≥98% (HPLC)
form
powder
color
faint green to dark gray
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
−20°C
Biochem/physiol Actions
ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.
Selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Tarsis F Brust et al.
Science signaling, 10(467) (2017-02-23)
Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that inhibitors of AC1 may be useful for treating pain and opioid dependence.
Xiang Li et al.
Microbiology (Reading, England), 170(6) (2024-06-25)
Bacterial infection is a dynamic process resulting in a heterogenous population of infected and uninfected cells. These cells respond differently based on their bacterial load and duration of infection. In the case of infection of macrophages with Crohn's disease (CD)
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