SML2114
ZD7155 hydrochloride
≥97% (HPLC)
别名:
5,7-Diethyl-3,4-dihydro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride, ZD 7155
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C26H26N6O · HCl
化学文摘社编号:
分子量:
474.99
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H
SMILES string
CCC1=C(C2=CC(CC)=N1)CCC(N2CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=O.Cl
InChI key
NAGGAAHTUXEGFG-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
Selective Angiotensin II AT1 antagonist
ZD7155 is a potent selective Angiotensin II AT1 antagonist. In one study ZD 7155 was found to be longer-acting and approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response.
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Signal Transduction and Targeted Therapy
Aung Than, Shaohai Xu, Ru Li, MelvinKhee-Shing Leow, Lei Sun and Peng Chen
Nature Chemical Biology, 2 (2017)
Haitao Zhang et al.
Nature, 544(7650), 327-332 (2017-04-06)
The angiotensin II receptors AT
I L Junggren et al.
The Journal of pharmacy and pharmacology, 48(8), 829-833 (1996-08-01)
Binding experiments show that ZD 7155 is a potent angiotensin II type 1 receptor antagonist. In this study this novel substance was studied in normotensive and hypertensive rats. The relative potency and duration of the antihypertensive effects of ZD 7155
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持