SML2114
ZD7155 hydrochloride
≥97% (HPLC)
别名:
5,7-Diethyl-3,4-dihydro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride, ZD 7155
方案
≥97% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CCC1=C(C2=CC(CC)=N1)CCC(N2CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=O.Cl
InChI
1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H
InChI key
NAGGAAHTUXEGFG-UHFFFAOYSA-N
生化/生理作用
Selective Angiotensin II AT1 antagonist
ZD7155 is a potent selective Angiotensin II AT1 antagonist. In one study ZD 7155 was found to be longer-acting and approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
此项目有
历史批次信息供参考:
I L Junggren et al.
The Journal of pharmacy and pharmacology, 48(8), 829-833 (1996-08-01)
Binding experiments show that ZD 7155 is a potent angiotensin II type 1 receptor antagonist. In this study this novel substance was studied in normotensive and hypertensive rats. The relative potency and duration of the antihypertensive effects of ZD 7155
Signal Transduction and Targeted Therapy
Aung Than, Shaohai Xu, Ru Li, MelvinKhee-Shing Leow, Lei Sun and Peng Chen
Nature Chemical Biology, 2 (2017)
Haitao Zhang et al.
Nature, 544(7650), 327-332 (2017-04-06)
The angiotensin II receptors AT
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