SML2118
HA15
≥98% (HPLC)
别名:
N- [4- [3-[[[5-（二甲基氨基）-1-萘基]磺酰基]氨基]苯基] -2-噻唑基]-乙酰胺
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C23H22N4O3S2
化学文摘社编号:
分子量:
466.58
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
HA15, ≥98% (HPLC)
InChI
1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
InChI key
LBSMEKVVMYSTIH-UHFFFAOYSA-N
SMILES string
CC(NC1=NC(C2=CC=CC(NS(C3=C(C=CC=C4N(C)C)C4=CC=C3)(=O)=O)=C2)=CS1)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
BiP/GRP78/HSPA5 伴侣的选择性配体，增加内质网应激，导致多种癌细胞系自噬和凋亡
HA15 是 BiP/GRP78/HSPA5 伴侣的选择性配体，可增加内质网应激，导致包括黑素瘤细胞在内的多种癌细胞自噬和凋亡。HA15 抑制 BiP 的 ATPase 活性。Ha15 抑制了注射 A375 黑色素瘤细胞的小鼠的肿瘤发展。
存储类别
11 - Combustible Solids
wgk
WGK 3
Michaël Cerezo et al.
Cancer cell, 29(6), 805-819 (2016-05-31)
We have discovered and developed a series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. Our
Michaël Cerezo et al.
Autophagy, 13(1), 216-217 (2016-10-30)
Treatment of melanoma has significantly advanced over the last decade, with the development of targeted therapies against the MAPK pathway and immunotherapies to reactivate antitumor immunity. Unfortunately, currently more than 50% of patients are in treatment failure. Thus, identification of
Rossella Benedetti et al.
Biomedicines, 9(9) (2021-09-29)
Polyphenols have been shown to possess several beneficial properties, including properties involved in the prevention or treatment of cancer. Among these polyphenols, a leading role is played by dihydroxyphenylethanol (DPE), the most powerful antioxidant compound contained in the olive oil.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持