SML2120
Nifekalant hydrochloride
≥98% (HPLC)
别名:
6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN1C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)=CC(N(C)C1=O)=O.Cl
InChI
1S/C19H27N5O5.ClH/c1-21-17(14-18(26)22(2)19(21)27)20-9-11-23(12-13-25)10-3-4-15-5-7-16(8-6-15)24(28)29;/h5-8,14,20,25H,3-4,9-13H2,1-2H3;1H
InChI key
YPVGGQKNWAKOPX-UHFFFAOYSA-N
Biochem/physiol Actions
Nifekalant is a pure potassium channel blocker and class III antiarrhythmic. It has been used to treat arrhythmias and ventricular tachycardia.
Potassium channel blocker, Antiarrhythmic agent, class III
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Makoto Suzuki et al.
Journal of arrhythmia, 32(3), 186-190 (2016-06-30)
Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise. Recurrence is common and may worsen a patient׳s clinical course despite appropriate treatment. This study aimed to examine the effectiveness of antiarrhythmic drugs for suppression of VTs. In this
Sou Otuki et al.
Journal of electrocardiology, 50(3), 277-281 (2017-02-28)
Patients with repetitive ventricular tachyarrhythmias - so-called electrical storm - frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefore, we investigated the efficacy of stepwise administration of nifekalant
Takashi Tagami et al.
Resuscitation, 109, 127-132 (2016-08-29)
We evaluated the association between nifekalant or amiodarone on hospital admission and in-hospital mortality for cardiac arrest patients with persistent ventricular fibrillation on hospital arrival. This was a retrospective cohort study using the Japanese Diagnosis Procedure Combination inpatient database. We